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Mohan Singh Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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Parvesh Chaudhry Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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Eric Asselin Research Group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada

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Introduction It is generally accepted that successful implantation depends on the quality of blastocyst, a receptive endometrium and the synchronization between the developmental stages of the embryo itself. The key to this process is the dynamic

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Agnieszka Waclawik Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland

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Adam J Ziecik Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland

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Introduction Maternal recognition of pregnancy requires reciprocal communication between the pre-implantation conceptus (embryo and associated membranes) and maternal system: uterine endometrium and corpus luteum (CL). In the pig

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Josephine F Trott Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Katherine C Horigan Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Julia M Gloviczki Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Kristen M Costa Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Bradley A Freking Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Chantal Farmer Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Kanako Hayashi Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Thomas Spencer Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Joseph E Morabito Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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Russell C Hovey Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA
Lactation and Mammary Gland Biology Group, Department of Animal Science, US Meat Animal Research Center, Agriculture and Agri-Food Canada, Department of Physiology, Department of Animal Science, Department of Animal Science, The University of Vermont, 570 Main Street, Burlington, Vermont 05405, USA

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ruminant trophoblast cells produce placental lactogen (reviewed by Soares 2004 ), the endometrium and placenta of pigs is considered to secrete neither PRL nor placental lactogen ( Forsyth 1974 , DeHoff 1986 , Young & Bazer 1989 ). While these data

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Z Cheng Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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M Elmes Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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S E Kirkup Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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E C Chin Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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D R E Abayasekara Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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D C Wathes Reproduction and Development Group, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK

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endometrium ( Gross et al . 1998 , Reese et al . 2000 , Loftin et al . 2002 ). In the ewe, however, COX-2 expression in the endometrium is increased during both spontaneous and dexamethasone (DEX)-induced labour, whereas there is no change in COX-1

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Taisuke Mori Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Fumitake Ito Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Hiroshi Matsushima Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Osamu Takaoka Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Akemi Koshiba Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Yukiko Tanaka Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Izumi Kusuki Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Jo Kitawaki Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

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Introduction Endometriosis is defined as the presence of endometrium-like tissues at extra-uterine sites. Clinical symptoms associated with endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility ( Giudice 2010 ). There

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Yaxiong Huang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Zihan Wang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Bin Li Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Lina Ke Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Yao Xiong Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Yuanzhen Zhang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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EM, and they also experience a higher rate of pregnancy-related complications ( Breintoft et al. 2021 , Corachan et al. 2021 ). Recent studies have indicated that the nonreceptive endometrium plays a crucial role in infertility among EM patients

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Alison E Wallace MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Douglas A Gibson MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Philippa T K Saunders MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Henry N Jabbour MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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concept that the normal cycling endometrium can be considered as a site of regular, repeated, inflammation will be considered, as will aspects of this process that may contribute to cancer development. Additionally, hormonal and genetic changes which occur

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Michiyo Tanikawa Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Hwa-Yong Lee Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Kikuko Watanabe Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Magdalena Majewska Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Dariusz J Skarzynski Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Soo-Bong Park Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Dong-Seok Lee Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Choon-Keun Park Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Tomas J Acosta Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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Kiyoshi Okuda Laboratory of Reproductive Endocrinology, Division of Applied Life Science, Department of Reproductive Immunology, National Institute of Animal Science, Department of Animal Biotechnology, School of Life Sciences & Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan

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(PGE2) has luteotropic and luteoprotective properties ( Reynold et al . 1981 , Weems et al . 1998 ). Although both PGE2 and PGF2α are secreted by bovine endometrium throughout the estrous cycle ( Miyamoto et al . 2000 , Murakami et al . 2001

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Diletta Piccirilli Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Enke Baldini Department of Surgical Sciences, ‘Sapienza’ University of Rome, Rome, Italy

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Micol Massimiani Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Antonella Camaioni Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Antonietta Salustri Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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Roberta Bernardini Department of Biology, NSTA, II University of Rome, Tor Vergata, Italy

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Marco Centanni Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy

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Salvatore Ulisse Department of Surgical Sciences, ‘Sapienza’ University of Rome, Rome, Italy

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Costanzo Moretti Department of Systems’ Medicine University of Rome Tor Vergata, UOC of Endocrinology and Diabetes, Section of Reproductive Endocrinology Fatebenefratelli Hospital, ‘Isola Tiberina’, Rome, Italy

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Luisa Campagnolo Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

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, Seshagiri et al . 2002 ), and the local production of potential zona-lysins, involved in the digestion of the ZP, produced by both the embryo and the endometrium ( Vu et al . 1997 , Mishra & Seshagiri 2000 ). These proteases may play a crucial role in the

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M A J Hervé INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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G Meduri INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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F G Petit INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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T S Domet INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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G Lazennec INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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S Mourah INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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M Perrot-Applanat INSERM U553, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
INSERM U716, Institut Universitaire d’Hématologie, Hôpital Saint-Louis/Bâtiment INSERM, 1 avenue Claude Vellefaux, 75010 Paris, France
Unité INSERM 540, Montpellier, France

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-Applanat 2000 ). Physiological angiogenesis is also required to support endometrial regeneration after shedding of the uterine surface in the absence of implantation and to support the proliferation of the human endometrium during the menstrual cycle under the

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