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A. L. C. WALLACE
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B. D. STACY
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G. D. THORBURN
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Since there are in-vivo effects of growth hormone (GH) on cartilage and adipose tissue which cannot be duplicated in vitro (Salmon & Daughaday, 1957; Daughaday & Reeder, 1966; Goodman, 1968) it has been postulated that pituitary GH is modified in the body before exerting its peripheral action.

In sheep, labelled GH is altered by the kidneys and returned to the circulation in an immunologically modified form (Wallace, Stacy & Thorburn, 1969). The altered material may still be biologically active and responsible for some of the observed effects of pituitary GH. We used the fat mobilizing action of GH in sheep (Bassett & Wallace, 1966) to test whether nephrectomy had an effect on the biological activity of injected GH.

The sheep were fasted for 24 h before the start of all experiments and throughout the experimental period. Blood samples were collected into heparinized tubes from jugular cannulae inserted the day before

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0480297
Volume/Issue:
Volume 48: Issue 2
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Rosemari Otton
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Danielly Oliveira da Silva
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Thais Regina Campoio
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Leonardo R Silveira Biological Sciences and Health Center (CCBS), Department of Physiology and Biophysics, Cruzeiro do Sul University, Regente Feijó Avenue, 1295, Analia Franco, 03342-000 São Paulo, Brazil

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Maria Oliveira de Souza Biological Sciences and Health Center (CCBS), Department of Physiology and Biophysics, Cruzeiro do Sul University, Regente Feijó Avenue, 1295, Analia Franco, 03342-000 São Paulo, Brazil

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Elaine Hatanaka Biological Sciences and Health Center (CCBS), Department of Physiology and Biophysics, Cruzeiro do Sul University, Regente Feijó Avenue, 1295, Analia Franco, 03342-000 São Paulo, Brazil

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Rui Curi Biological Sciences and Health Center (CCBS), Department of Physiology and Biophysics, Cruzeiro do Sul University, Regente Feijó Avenue, 1295, Analia Franco, 03342-000 São Paulo, Brazil

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Article Type:
Retraction
DOI:
https://doi.org/10.1530/JOE-07-0195er
Volume/Issue:
Volume 217: Issue 2
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Rosemari Otton
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Danielly Oliveira da Silva
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Thais Regina Campoio
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Leonardo R Silveira
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Maria Oliveira de Souza
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Elaine Hatanaka
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Rui Curi
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Article Type:
Addendum
DOI:
https://doi.org/10.1530/JOE-07-0195e
Volume/Issue:
Volume 216: Issue 3
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A Margot Umpleby Diabetes and Metabolic Medicine, Faculty of Health and Metabolic Sciences, University of Surrey, Leggett Building, Daphne Jackson Road, Manor Park, Guildford GU2 7WG, UK

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mellitus and atherosclerotic cardiovascular disease ( Hubert et al . 1983 , de Marco et al . 1999 ). Fatty acids are one of the mediators of insulin resistance ( Boden 1998 ), and an imbalance in fatty acid metabolism results in the accumulation of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0610
Volume/Issue:
Volume 226: Issue 3
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M Kurtz Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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E Capobianco Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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V Careaga Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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N Martinez Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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M B Mazzucco Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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M Maier Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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A Jawerbaum Laboratory of Reproduction and Metabolism, UMYMFOR (CONICET‐UBA), CEFyBO‐CONICET, School of Medicine and

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PPAR ligands are certain lipids and lipid derivatives such as unsaturated fatty acids and eicosanoids, capable of activating one or more PPAR isoforms ( Hihi et al . 2002 ). Indeed, the three PPAR isotypes, named PPARα, PPARγ, and PPARδ, can be

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0362
Volume/Issue:
Volume 220: Issue 3
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Yue Yu Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Rui Guo Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Yunjin Zhang Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Hongbo Shi College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

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Haoran Sun College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

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Xia Chu Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Xiaoyan Wu Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Huimin Lu Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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Changhao Sun Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

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, Li et al . 2012 , GBD et al . 2016 , Chen et al . 2017 ). Chronic exposure to elevated saturated fatty acid (SFA) is a major risk factor for β-cell dysfunction that can accelerate the progression of T2DM ( Welsh et al . 2005 , Risérus et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0055
Volume/Issue:
Volume 246: Issue 1
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Dan-Dan Feng Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China
Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China

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Yu-Feng Zhao Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China

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Zi-Qiang Luo Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China

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Damien J Keating Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China

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Chen Chen Department of Physiology, Prince Henry's Institute of Medical Research, Xiangya Medical School, Central South University, Changsha, 410078 People's Republic of China

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Introduction Pancreatic β-cells secrete insulin in response to stimulation by nutrients such as glucose and free fatty acids (FFAs). Glucose-stimulated insulin secretion (GSIS) plays an important role in maintaining glucose homeostasis. In

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0426
Volume/Issue:
Volume 196: Issue 2
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Michelle M Chen
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Clarence Hale
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Shanaka Stanislaus
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Jing Xu
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Murielle M Véniant Department of Cardiometabolic Disorders, Amgen Inc., Thousand Oaks, California, USA

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steps were followed as described earlier. Measurement of liver and fecal cholesterol and fatty acids Fecal and liver total lipids were extracted from dried powdered feces using chloroform:methanol (2:1) according to the classic Folch method

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0727
Volume/Issue:
Volume 237: Issue 2
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Hannah M Eggink Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Lauren L Tambyrajah Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Rosa van den Berg Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Isabel M Mol Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Jose K van den Heuvel Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Martijn Koehorst Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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Albert K Groen Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Department of Vascular Medicine, Amsterdam Diabetes Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Andries Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Johannes A Romijn Department of Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Maarten R Soeters Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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after preparation. To study the uptake of triglyceride-derived fatty acids, mice were fasted for 4 h and blood was drawn via the tail vein to determine BA levels (for the complete protocol, Supplementary methods, see section on supplementary data

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0503
Volume/Issue:
Volume 236: Issue 2
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Rengasamy Palanivel Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Vivian Vu Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Min Park Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Xiangping Fang Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Gary Sweeney Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3

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Article Type:
Addendum
DOI:
https://doi.org/10.1677/JOE-08-0336e
Volume/Issue:
Volume 200: Issue 2
Free access