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Andreas Nygaard Madsen, Gitte Hansen, Sarah Juel Paulsen, Kirsten Lykkegaard, Mads Tang-Christensen, Harald S Hansen, Barry E Levin, Philip Just Larsen, Lotte Bjerre Knudsen, Keld Fosgerau, and Niels Vrang

the development of obesity and metabolic alterations in the DIO and DR rats fed either a high-fat diet or normal chow diet for 9 months. In addition, we examined the body weight reduction and metabolic effects after administration of sibutramine and

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M K Judge, Y Zhang, and P J Scarpace

levels and resistance to high-fat (HF) diet-induced obesity, even when they consume the same amount of food as controls ( Matias et al . 2006 ). Recent evidence indicates that the EC system may function to promote hyperphagia and the consumption of

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Myat Theingi Swe, Laongdao Thongnak, Krit Jaikumkao, Anchalee Pongchaidecha, Varanuj Chatsudthipong, and Anusorn Lungkaphin

examined. The aim of the current study was to investigate the effect of dapagliflozin on the expression levels of renal cortical gluconeogenic enzymes in high-fat diet-fed obese rats. In addition, the possible underlying molecular mechanisms by which

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Júlio Cezar de Oliveira, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, Luiz Felipe Barella, Rosiane Aparecida Miranda, Ananda Malta, Claudinéia Conationi da Silva Franco, Tatiane Aparecida da Silva Ribeiro, Rosana Torrezan, Clarice Gravena, and Paulo Cezar de Freitas Mathias

Student's t -test. NS, no significant difference. Discussion A 30-day reduction in protein in the diet (4%) from 30 to 60 days of age led the 120-day-old male adult rats to develop high fat tissue accumulation, similar to what occurs with the same

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Bishnu Adhikari, Prabhat Khanal, and Mette Olaf Nielsen

response to nutrient restriction during foetal life ( Reusens & Remacle 2006 ). We have previously reported that exposure to an obesogenic, high-fat diet in early postnatal life resulted in hyperglycaemia and insulin resistance in adolescent lambs with a

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Sami Ayari, Eva Gil-Iturbe, Léa le Gléau, Céline Osinski, Nathalie Kapel, Hedi Antoine Soula, Armelle Leturque, Fabrizio Andreelli, Karine Clément, Patricia Serradas, and Agnès Ribeiro

of a role of HNF-4γ in metabolic disorders related to intestine, we submitted the constitutive Hnf4g gene invalidation model to a high-fat/high-fructose (HF-HF) diet for 6 weeks, in order to induce obesity and T2D. Materials and methods

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Yuriko Sakai, Hideyuki Arie, Yinhua Ni, Fen Zhuge, Liang Xu, Guanliang Chen, Naoto Nagata, Takuya Suzuki, Shuichi Kaneko, Tsuguhito Ota, and Mayumi Nagashimada

for the study of the NASH model. The number of natural killer T (NKT) cells in the liver decreases in mice fed a high-fat diet ( Li et al. 2005 ). Additionally, the number of NKT cells in liver biopsies from patients with hepatic steatosis is low

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Wanpitak Pongkan, Hiranya Pintana, Sivaporn Sivasinprasasn, Thidarat Jaiwongkam, Siriporn C Chattipakorn, and Nipon Chattipakorn

cycle) and fed with standard laboratory chow (normal diet (ND)) or a high-fat diet (HFD) and water. Both food and water were given ad libitum . Orchiectomy procedure Rats were anesthetized and maintained using isoflurane 2–3% and the scrotal

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M J Devlin, D J Brooks, C Conlon, M van Vliet, L Louis, C J Rosen, and M L Bouxsein

bone and fat may be particularly important in young, rapidly growing animals, as CR in young mice is associated with both low bone mass and high marrow adiposity ( Devlin et al . 2010 ), whereas CR in older mice has more modest effects on bone and may

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Hassina Ould Hamouda, Bernadette Delplanque, Yacir Benomar, Delphine Crépin, Laure Riffault, Pascale LeRuyet, Cécile Bonhomme, and Mohammed Taouis

and protein in elderly rats. Indeed, despite its high saturated fatty acid content, milk fat has been reported to improve insulin sensitivity ( Holmberg & Thelin 2013 ) and to reduce central obesity ( German et al . 2009 ). Furthermore, there is no