, a CD14 + monocyte/macrophage-restricted receptor and an interferon-stimulated gene (ISG) that is upregulated by type I IFN, was increased in uGD patients at both the monocyte mRNA and serum levels. Inhibiting monocyte SIGLEC1 expression caused
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Yanqiu Wang, Zhou Jin, Jiajun Sun, Xinxin Chen, Pu Xie, Yulin Zhou, and Shu Wang
K Vagnerová, M Kverka, P Klusoňová, P Ergang, I Mikšík, H Tlaskalová-Hogenová, and J Pácha
localized in the cells of lamina propria ( Whorwood et al. 1994 ). This matches with the findings of 11HSD1 in fibroblasts ( Hammami & Siiteri 1991 ), macrophages ( Thieringer et al. 2001 ), and lymphocytes ( Zhang et al. 2005 ). Consistent with the
Farhana Naznin, Koji Toshinai, T M Zaved Waise, Cherl NamKoong, Abu Saleh Md Moin, Hideyuki Sakoda, and Masamitsu Nakazato
12 weeks. Expression of the ghrelin receptor in both the nodose ganglion and hypothalamus were downregulated in HFD-fed mice. We also investigated inflammation in the nodose ganglion and hypothalamus by performing immunohistochemistry of macrophages
Jessica R Mader, Zachary T Resch, Gary R McLean, Jakob H Mikkelsen, Claus Oxvig, Ronald J Marler, and Cheryl A Conover
mice. b Significant difference between 18-month-old non-diabetic and diabetic WT mice. Immunohistochemistry De-paraffinized sections of mouse kidney were stained for macrophages using F4/80 as primary antibody. Slides were rinsed with Tris
Zhongyang Lu, Xiaoming Zhang, Yanchun Li, Junfei Jin, and Yan Huang
by endogenous ligands that are likely to be related to hyperlipidemia in Apoe −/− mice. Indeed, in vitro studies have shown that minimally modified LDL (mmLDL) is capable of inducing inflammatory cytokine production in macrophages by engaging TLR4
Sébastien Desarzens and Nourdine Faresse
-inflammatory genes and macrophage infiltration into adipose tissue in obese mice ( Guo et al . 2008 , Hirata et al . 2009 , Lee et al . 2014 ). Conversely, selective activation of GR by dexamethasone decreases pro-inflammatory cytokine expression and macrophage
Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, Stephanie Li Ying Soh, Guanghou Shui, Markus R Wenk, Kevin L Grove, George K Radda, Weiping Han, and Xiaoqiu Xiao
local increases in the production of non-esterified fatty acids (NEFA). Through increased expression of pro-inflammatory cytokines and chemokines, and infiltration of macrophages and other immune cells into adipose tissue, obesity-induced inflammation is
Kayo Mori, Akiko Mizokami, Tomomi Sano, Satoru Mukai, Fumitaka Hiura, Yasunori Ayukawa, Kiyoshi Koyano, Takashi Kanematsu, and Eijiro Jimi
significance was set at P < 0.05. Results Prolonged RANKL stimulation induces Tnfa expression via the non-canonical NF-κB pathway in BMCs Adipose tissue macrophages, some recruited from bone marrow-derived macrophages, contribute to
Yuichi Kikuchi, Muneharu Yamada, Toshihiko Imakiire, Taketoshi Kushiyama, Keishi Higashi, Naomi Hyodo, Kojiro Yamamoto, Takashi Oda, Shigenobu Suzuki, and Soichiro Miura
prevented hypertensive renal injuries by inhibiting expression of extracellular matrix genes, oxidative stress, cell proliferation, and macrophage infiltration in several hypertensive models ( Kanda et al. 2003 , Nishikimi et al. 2004 , Ishikawa et al
Eddy Himpe, Céline Degaillier, Astrid Coppens, and Ron Kooijman
of inflammation by chemoattractants such as interleukin-8 (IL8). This inflammatory cytokine is produced by monocytes and macrophages, and is also one of the most abundant cytokines produced by neutrophils, which triggers degranulation and oxidative
