been considered in the context of AD, only recently have they been examined in the context of whole body metabolism and metabolic disease states. Interestingly, a number of AD animal models with increased circulating Aβ levels are reported to
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Juliane K Czeczor, Amanda J Genders, Kathryn Aston-Mourney, Timothy Connor, Liam G Hall, Kyoko Hasebe, Megan Ellis, Kirstie A De Jong, Darren C Henstridge, Peter J Meikle, Mark A Febbraio, Ken Walder, and Sean L McGee
Ananda Malta, Júlio Cezar de Oliveira, Tatiane Aparecida da Silva Ribeiro, Laize Peron Tófolo, Luiz Felipe Barella, Kelly Valério Prates, Rosiane Aparecida Miranda, Ghada Elmhiri, Claudinéia Conationi da Silva Franco, Aryane Rodrigues Agostinho, Amanda Bianchi Trombini, Audrei Pavanello, Clarice Gravena, Latifa Abdennebi-Najar, and Paulo Cezar de Freitas Mathias
Introduction The developmental origins of health and disease (DOHaD) concept originates from the epidemiological, clinical, and experimental evidence that insults during early life can program metabolic dysfunctions later in life and cause great
Daniel J Tobiansky, George V Kachkovski, Reilly T Enos, Kim L Schmidt, E Angela Murphy, and Kiran K Soma
% of kcal; World Health Organization 2015 ) in the USA and other countries ( Welsh et al . 2011 ). Excess sugar consumption is associated with type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), and certain cancers
Cathy A Guo and Shaodong Guo
hyperglycemia-induced cardiac dysfunction, independent of hypertension and coronary artery diseases ( Rubler et al . 1972 ). Over the past decades, insulin resistance is believed to be a primary contributor to metabolic and cardiovascular dysfunction and serves
Stuart A Morgan, Laura L Gathercole, Zaki K Hassan-Smith, Jeremy Tomlinson, Paul M Stewart, and Gareth G Lavery
pre-receptor GC metabolism in contributing to age-associated chronic disease, but raises an important question: ‘Precisely how does 11β-HSD1 drive age-related metabolic dysfunction?’ Previous studies have shown 11β-HSD1 to increase with age in the skin
Nicole Draper and Paul M Stewart
and metabolic syndrome Obesity is a major risk factor for cardiovascular disease, diabetes and premature mortality. However, it is the amount of omental fat that has been shown to correlate strongly with glucose intolerance and insulin
Paz Vital, Elena Larrieta, and Marcia Hiriart
Introduction Diabetes mellitus is a common metabolic disease. Type 2 diabetes is rapidly becoming pandemic, and although the origin of this disease is not entirely clear, it is accepted that insulin resistance is important in its
Isis Gabrielli Barbieri de Oliveira, Marcos Divino Ferreira Junior, Paulo Ricardo Lopes, Dhiogenes Balsanufo Taveira Campos, Marcos Luiz Ferreira-Neto, Eduardo Henrique Rosa Santos, Paulo Cezar de Freitas Mathias, Flávio Andrade Francisco, Bruna Del Vechio Koike, Carlos Henrique de Castro, André Henrique Freiria-Oliveira, Gustavo Rodrigues Pedrino, Rodrigo Mello Gomes, and Daniel Alves Rosa
Devaraj S 2017 Impact of time-restricted feeding and dawn-to-sunset fasting on circadian rhythm, obesity, metabolic syndrome, and nonalcoholic fatty liver disease . Gastroenterology Research and Practice 2017 3932491 . ( https://doi.org/10
Isabel Huang-Doran, Alison Sleigh, Justin J Rochford, Stephen O'Rahilly, and David B Savage
the relationship between obesity, insulin resistance and metabolic disease are incompletely understood, and the contributory genes are poorly defined. A powerful approach to this daunting problem – and one that is potentially applicable to any complex
Malin Fex, Lisa M Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V Sharoyko, David G Nicholls, Peter Spégel, and Hindrik Mulder
changes in cellular function and demands, a plasticity which serves to optimize mitochondrial function and metabolism for every specific situation. A number of mouse models have been used to study mitochondrial dysfunction in metabolic diseases ( Supale
