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Chau Thien Tay Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Rhonda Garrad Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Aya Mousa Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Mahnaz Bahri Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Anju Joham Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Helena Teede Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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manifestations arise in childhood and health impacts evolve across adolescent years and adult life ( Teede et al. 2010 ). PCOS has significant metabolic (obesity, metabolic syndrome, impaired glucose tolerance, type 2 diabetes, cardiovascular risk factors

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0232
Volume/Issue:
Volume 257: Issue 3
Free access
Gabriel Forn-Cuní Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Monica Varela Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Conrado M Fernández-Rodríguez Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Antonio Figueras Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Beatriz Novoa Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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diseases are part of a condition termed metabolic syndrome. The hepatic component of metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This term comprises a wide range of progressive liver injuries including bland steatosis, variable degrees

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0398
Volume/Issue:
Volume 224: Issue 2
Free access
Eun-Kyung Choi
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Woon-Ki Kim
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Ok-Joo Sul
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Yun-Kyung Park
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Eun-Sook Kim Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Jae-Hee Suh Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Rina Yu Department of Biological Sciences, Department of Endocrinology, Department of Pathology, Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea

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Hye-Seon Choi
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role of TNFRSF14 in OVX-induced metabolic disturbances could aid in the design of a novel therapy for postmenopausal syndrome. Declaration of interest The authors declare that there is no conflict of interest that could be perceived as prejudicing the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0341
Volume/Issue:
Volume 220: Issue 1
Free access
Malin Fex Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Lisa M Nicholas Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Neelanjan Vishnu Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Anya Medina Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Vladimir V Sharoyko Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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David G Nicholls Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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Peter Spégel Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden
Department of Chemistry, Center for Analysis and Synthesis, Lund University, Sweden

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Hindrik Mulder Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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) of patients with T2D and metabolic traits have been published ( Saxena et al . 2007 , Scott et al . 2007 , Sladek et al . 2007 , Zeggini et al . 2007 , Gaulton et al . 2015 , Fuchsberger et al . 2016 ). The number of gene loci conferring

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0367
Volume/Issue:
Volume 236: Issue 3
Free access
J Hoppmann
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N Perwitz
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B Meier
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M Fasshauer Department of Internal Medicine I, Department of Internal Medicine III, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany

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D Hadaschik
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H Lehnert
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J Klein
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metabolic syndrome ( Hotamisligil et al . 1993 , 1995 ). The crosstalk between adipocytes and macrophages which infiltrate adipose tissue in obesity is considered to be crucial for the development of the pro-inflammatory state ( Bluher 2008 ). To date, the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0292
Volume/Issue:
Volume 204: Issue 2
Free access
Sieneke Labruijere Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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E Leonie A F van Houten Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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René de Vries Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Usha M Musterd-Bagghoe Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Ingrid M Garrelds Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Piet Kramer Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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A H Jan Danser Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Carlos M Villalón Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Jenny A Visser Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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Antoinette MaassenVanDenBrink Division of Vascular Medicine and Pharmacology, Division of Endocrinology, Departamento de Farmacobiología, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands

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are still unclear, but high levels of androgens are considered to play a crucial role in the etiology. PCOS patients suffer from dyslipidemia, obesity and metabolic syndrome ( Wild 2002 , Glueck et al . 2009 ), resulting in an increased risk for type

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0094
Volume/Issue:
Volume 218: Issue 2
Free access
Jinyu Ma Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yuejun Wang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Jie Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Shouping Zhang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Yinuo Yang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China

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Cheng Sun Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education; NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University,Nantong, China
Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China

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obesity at the early stages of the disease ( Ezenwaka et al. 2014 , Heianza et al. 2015 ). Abdominal obesity is an important cause of metabolic syndromes and impairs glucose tolerance ( Hossain et al. 2007 ). Therefore, slow or prevent body weight

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0472
Volume/Issue:
Volume 249: Issue 3
Restricted access
Cássio M Villicev Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Fatima R S Freitas Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Marcelo S Aoki Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Cássio Taffarel Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Thomas S Scanlan Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Anselmo S Moriscot Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Miriam O Ribeiro Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Antonio C Bianco Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Cecília H A Gouveia Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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result in some therapeutically desirable effects, such as increased metabolic rate, lipolysis, cholesterol lowering, improvement of heart contractility and thyroid-stimulating hormone (TSH) suppression, which is beneficial in patients with thyroid cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07066
Volume/Issue:
Volume 193: Issue 1
Free access
Milos Lazic
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Fraser Aird
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Jon E Levine Division of Endocrinology, Department of Neurobiology and Physiology, Metabolism and Molecular Medicine, Northwestern University, Chicago, Illinois 60611, USA

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Andrea Dunaif
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have an increased prevalence of hyperandrogenemia, insulin resistance, and metabolic syndrome ( Sam et al . 2005 , 2006 ). Brothers of women with PCOS have elevated levels of dehydroepiandrosterone sulfate ( Legro et al . 2002 ) and metabolic

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0263
Volume/Issue:
Volume 208: Issue 3
Free access
Carla Tatone Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giovanna Di Emidio Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Martina Placidi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giulia Rossi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Stefania Ruggieri Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Chiara Taccaliti Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Angela D’Alfonso Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Fernanda Amicarelli Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Maurizio Guido Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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hyperinsulinemia, type 2 diabetes mellitus, obesity, dyslipidemia, metabolic syndrome, and cardiovascular complications (reviewed by Carvalho et al. 2018 ). Insulin resistance is observed up to 47% in lean PCOS and up to 76% in obese PCOS ( Diamanti

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0143
Volume/Issue:
Volume 251: Issue 2
Free access