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C E Waters, A Stevens, A White, and D W Ray

receptor is capable of nuclear translocation and binding to DNA. Deletion of the GR C-terminal (ΔAF-2), including the ligand binding and AF-2 transactivation domains, showed a significant increase in activity compared with full-length receptor in the

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Tony K S Ku and David L Crowe

( Couse & Korach 1999 ). ERs belong to the superfamily of nuclear hormone receptors that are ligand-dependent transcription factors ( Mangelsdorf et al. 1995 ). The ERα binds to estrogen response elements in the promoters of responsive genes. A number of

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Jing Li, Pan-Pan Zhao, Ting Hao, Dan Wang, Yu Wang, Yang-Zi Zhu, Yu-Qing Wu, and Cheng-Hua Zhou

et al . (1999) found that GPR14, a kind of orphan G protein-coupled receptor, is the only high-affinity receptor of U-II. U-II and its special receptor, GPR14, are widely distributed in peripheral and central organs. With further research, it has

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Akira Takeshita, Keiji Inagaki, Junko Igarashi-Migitaka, Yasunori Ozawa, and Noriyuki Koibuchi

-dependent membrane efflux pump to exclude anticancer drugs from tumor cells. Thus, MDR1 decreases intracellular drug concentrations to confer a MDR (for reviews, see Loo & Clarke 1999 , Robert 1999 , Gottesman et al. 2002 ). The orphan nuclear receptor

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Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole, and Jeremy W Tomlinson

nuclear receptors including the LXRs, GR, PXR and the retinoic acid receptor-related orphan receptors (RORs) ( Ma & Nelson 2019 ). In this regard, there is compelling evidence on the role of oxysterols as important mediators of metabolic syndrome

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Marian Joëls and E Ronald de Kloet

nuclear MRs, which are already substantially occupied under rest ( Joëls et al . 2008 , Groeneweg et al . 2011 ). Activation of the membrane MR results in the downregulation of the presynaptic Type 2 metabotropic glutamate (mGlu2) receptor presumably in

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M T Rae, D Niven, A Ross, T Forster, R Lathe, H O D Critchley, P Ghazal, and S G Hillier

contraceptive usage. HOSE cells are believed to be steroid responsive on the basis that exposure to ovarian steroids in vitro affects HOSE cell proliferation ( Karlan et al. 1995 ) and that they express nuclear hormone receptors, including oestrogen receptor

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G M Ledda-Columbano, A Perra, M Pibiri, F Molotzu, and A Columbano

). Most of these actions are mediated by thyroid hormone ( l -tri-iodothyronine; T3) nuclear receptors (TRs) that are encoded by two genes (α and β) and are expressed as several isoforms ( Cheng 1995 , Lazar 1993 , Hoppenheimer et al. 1996 , Yen 2001

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Richard Hanna, Yefei Pang, Peter Thomas, and Yong Zhu

-sensitive G i pathway ( Karteris et al. 2006 ). However, only mPRα appears to mediate progesterone phosphorylation of the myosin light chain through activation of p38MAPK and downregulate expression of the nuclear receptor co-activator, SRC2, in these

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Alberto Dinarello, Giorgio Licciardello, Camilla Maria Fontana, Natascia Tiso, Francesco Argenton, and Luisa Dalla Valle

Dias M Bernardi Videira N Bruder M Amorim Amato A Migliorini Figueira AC 2019 Modulation of nuclear receptor function: targeting the protein-DNA interface . Molecular and Cellular Endocrinology 484 1 – 14 . (