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JAN-ÅKE GUSTAFSSON
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MAGNUS INGELMAN-SUNDBERG
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ÅKE STENBERG
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FRIEDMUND NEUMANN
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SUMMARY

The metabolism of [4-14C]4-androstene-3, 17-dione, [4-14C]5α-androstane-3α, 17β-diol and 1,2-3H]5α-androstane-3α, 17β-diol 3,17-disulphate was studied using the microsomal fraction and the metabolism of [4-14C]4-androstene-3, 17-dione was studied using the 105 000 g supernatant fraction of liver from male and female rats aged 5 months that had been treated with cyproterone acetate before (from day 13 of pregnancy) and after birth (until 3 weeks of age). Nearly all sex-dependent enzyme activities in the treated male rats were changed in a direction characteristic of female rats: 5α-reductase active on 4-androstene-3, 17-dione increased in activity whereas 3β- and 17α-hydroxysteroid reductases and 6β- and 16α-hydroxylases active on 4-androstene-3, 17-dione and 2α-, 2β- and 18-hydroxylases active on 5α-androstane-3α, 17β-diol decreased in activity. Enzyme activities not under gonadal control, i.e. 3α- and 17β-hydroxysteroid reductases active on 4-androstene-3, 17-dione and 7α-hydroxylase active on both 4-androstene-3, 17-dione and 5α-androstane-3α, 17β-diol, were not affected by cyproterone acetate. The liver enzyme activities in treated female rats were generally not affected although significant effects were noted in two cases; in one of these (17α-hydroxysteroid reductase) a testosterone-like effect was observed.

The results obtained are probably best explained in the following way: treatment with the anti-androgen during the neonatal period results in less efficient imprinting of the hypothalamo-hypophysial system leading to less pronounced masculine setting of sex-dependent enzyme levels and also to a relative androgen unresponsiveness. It is suggested that the biochemical methods used in the present investigation may be used for more exact estimation of the degree of neonatal sexual differentiation of the hypothalamo-hypophysial system than biological and psychological methods previously available.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0640267
Volume/Issue:
Volume 64: Issue 2
Restricted access
M Tena-Sempere
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J Navarro
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L Pinilla
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LC Gonzalez
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I Huhtaniemi
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E Aguilar
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The biological actions of estrogens on target cells are mediated by two nuclear receptors: the estrogen receptor (ER) alpha and the recently characterized ER beta. In the male rat, the physiological role of estrogens involves multiple actions, from masculinization of brain areas related to reproductive function and sexual behavior to regulation of testicular development and function. Paradoxically, however, administration of high doses of estrogen during the critical period of neonatal differentiation results in an array of defects in the reproductive axis that permanently disrupt male fertility. The focus of this study was to characterize the effects and mechanism(s) of action of neonatal estrogenization on the pattern of testicular ER alpha and beta gene expression during postnatal development. To this end, groups of male rats were treated at day 1 of age with estradiol benzoate (500 microg/rat), and testicular ER alpha and ER beta mRNA levels were assayed by semi-quantitative RT-PCR from the neonatal period until puberty (days 1-45 of age). Furthermore, the expression of androgen receptor (AR) mRNA was evaluated, given the partially overlapping pattern of tissue distribution of ER alpha, ER beta and AR messages in the developing rat testis. In addition, potential mechanisms for neonatal estrogen action were explored. Thus, to discriminate between direct effects and indirect actions through estrogen-induced suppression of serum gonadotropins, the effects of neonatal estrogenization were compared with those induced by blockade of gonadotropin secretion with a potent LHRH antagonist in the neonatal period. Our results indicate that neonatal exposure to estrogen differentially alters testicular expression of alpha and beta ER messages: ER alpha mRNA levels, as well as those of AR, were significantly decreased, whereas relative and total expression levels of ER beta mRNA increased during postnatal/prepubertal development after neonatal estrogen exposure, a phenomenon that was not mimicked by LHRH antagonist treatment. It is concluded that the effect of estrogen on the expression levels of ER alpha and beta mRNAs probably involves a direct action on the developing testis, and cannot be attributed to estrogen-induced suppression of gonadotropin secretion during the neonatal period.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1650345
Volume/Issue:
Volume 165: Issue 2
Free access
Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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testing of this assumption was challenging because the inaccessibility and small size of the eutherian fetus at the time of sexual differentiation made a direct assessment of circulating androgens a challenge. Jean Wilson and his colleagues investigated

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0296
Volume/Issue:
Volume 258: Issue 3
Free access
Arnaud Jean Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris – Seine; Institut de Biologie Paris Seine, Paris, France

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Anne-Charlotte Trouillet Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris – Seine; Institut de Biologie Paris Seine, Paris, France

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Njiva Andry Andrianarivelo Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris – Seine; Institut de Biologie Paris Seine, Paris, France

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Sakina Mhaouty-Kodja Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris – Seine; Institut de Biologie Paris Seine, Paris, France

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Hélène Hardin-Pouzet Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris – Seine; Institut de Biologie Paris Seine, Paris, France

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Introduction Sexual behaviour in male rodents can be described as a series of behavioural elements cumulating in ejaculation. These involve approaches and olfactory investigations of the female during the motivational phase of sexual behaviour

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0025
Volume/Issue:
Volume 233: Issue 3
Free access
María Cecilia Ramirez Instituto de Biología y Medicina Experimental-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina

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Guillermina María Luque Instituto de Biología y Medicina Experimental-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina

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Ana María Ornstein Instituto de Biología y Medicina Experimental-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina

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Damasia Becu-Villalobos Instituto de Biología y Medicina Experimental-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina

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downstream mechanisms, which include the sexual differentiation of female and male predominant liver enzymes and secreted proteins. Gonadal steroids were administered only at birth in order to unravel the consequences of early steroid exposure in mice. The

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0276
Volume/Issue:
Volume 207: Issue 3
Free access
Lydie Naulé Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Marie Picot Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Mariangela Martini Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Caroline Parmentier Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Hélène Hardin-Pouzet Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Matthieu Keller Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Isabelle Franceschini Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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Sakina Mhaouty-Kodja Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224
Sorbonne Universités, Centre National de la Recherche Scientifique (CNRS) UMR 7224, Institut National de la Recherche Agronomique (INRA) UMR85, CNRS UMR 7247, Université François Rabelais, UPMC University Paris 06, UMR 7224

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& Lawson 1936 ) and acts as a partial agonist ( Delfosse et al . 2012 ). The sexual differentiation of reproductive behavior and neuroendocrine function in rodents occurs during the perinatal (late gestational and early neonatal) and postnatal periods

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0607
Volume/Issue:
Volume 220: Issue 3
Free access
Chandrika D Mahalingam Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Bharat Reddy Sampathi Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Sonali Sharma Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Tanuka Datta Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Varsha Das Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Abdul B Abou-Samra Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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Nabanita S Datta Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA
Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA
Division of Endocrinology, Barbara Ann Karmanos Cancer Institute, Cardiovascular Research Institute, Department of Internal Medicine, Wayne State University School of Medicine, 1107 Elliman Clinical Research Building, 421 East Canfield Avenue, Detroit, Michigan 48201, USA

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therapeutic approach for treating osteoporosis includes anabolic agents that promote osteoblastic differentiation leading to increased bone formation. Daily injection of parathyroid hormone (PTH), PTH (1–34), has been shown to be anabolic ( Greenfield 2012

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0372
Volume/Issue:
Volume 216: Issue 3
Free access
Zhihao Liu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Fengrui Wu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Baowei Jiao Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Xiuyue Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Chongjiang Hu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Baofeng Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Linyan Zhou Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Xigui Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Zhijian Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Yaoguang Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Yoshitaka Nagahama Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Christopher H K Cheng Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Deshou Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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sexually dimorphic and restricted to the testis ( Raymond et al. 1999 a , b , Kettlewell et al. 2000 , Shan et al. 2000 a , Smith et al. 2003 ). Moreover, Dmrt1 −/− knockout XY mice develop testicular differentiation failure ( Raymond et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0135
Volume/Issue:
Volume 194: Issue 1
Free access
Edouard G A Mills Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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Waljit S Dhillo Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK

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Alexander N Comninos Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK

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. Hormones and Behavior 94 53 – 60 . ( https://doi.org/10.1016/j.yhbeh.2017.06.006 ) 10.1016/j.yhbeh.2017.06.006 28645693 Bakker J Pierman S González-Martínez D 2010 Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0269
Volume/Issue:
Volume 239: Issue 1
Free access
Lili Chen Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Xiaolong Jiang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Haiwei Feng Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Hongjuan Shi Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Lina Sun Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Wenjing Tao Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Qingping Xie Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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Deshou Wang Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China

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formation . Molecular and Cellular Biology 28 803 – 813 . ( doi:10.1128/MCB.01226-07 ) Kobayashi T Nagahama Y 2009 Molecular aspects of gonadal differentiation in a teleost fish, the Nile tilapia . Sexual Development 3 108 – 117 . ( doi:10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0432
Volume/Issue:
Volume 228: Issue 3
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