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. The study groups were: (1) untreated LETO (lean control; n  = 5/time point) + vehicle (0.5% methylcellulose by oral gavage once daily; 1 µL/g), (2) untreated OLETF ( n  = 6/time point) + vehicle and (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day by

continues to mount showing that T2DM is more prevalent among subjects that were intrauterine growth restricted (IUGR) during fetal development, indicating that the defects in glucose homeostasis originate in utero ( Barker et al . 1993 , Ravelli et al

restriction period began. Rats were feed-restricted (R;−50% of their regular intake) for 90 days and were then allowed to refeed AL for 30 days with a CD, MSP, MRD, or FF diet, except for the R group, which was killed at the end of the food restriction period

day 0, and within 3 days the litters were restricted to nine to thirteen pups per litter. The pups were kept with their mother and were fed with tap water and a pelleted rat chow ad libitum (Altromin, Breeding diet, B&K Universal AB, Sweden

.cell.2005.05.027 ) Hatori M Vollmers C Zarrinpar A DiTacchio L Bushong EA Gill S Leblanc M Chaix A Joens M Fitzpatrick JA 2012 Time-restricted feeding without reducing caloric intake prevents metabolic diseases in

2 years of age, time point 0 h indicates samples taken from the female adult sheep in the fed state, 24- and 48-h samples were obtained after 24 and 48 h of fasting respectively and 72-h sample was taken 1 h after re-feeding. All other samples were

fellowships from CNPq during the present study. References Aceves C Escobar C Rojas-Huidobro R Vazquez-Martinez O Martinez-Merlos T Aguilar-Roblero R Diaz-Munoz M 2003 Liver 5′-deiodinase activity is modified in rats under restricted feeding

–Dawley (SD) pregnant rats (12 weeks old, 250–300 g, day 2 of pregnancy at the time of the experiment) obtained from Zhejiang Medical Science Academy (Hangzhou, China) were used to generate the offspring used in this study. The rats were housed in a 22 ± 1 °C

dietary intake can contribute to obesity development. It has been shown that early feeding conditions, the quantity and quality of food during gestation, or the postnatal development period may exert lifelong effects on body weight regulation ( Basset

function. Therefore, additional groups of male mice were fasted for 6 and 12 h during scotophase at the start of nocturnal activity, which would detect changes at a time of active feeding (note, the 24 and 48 h fast began and ended during photophase). In