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Ralf Baumeister Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany
ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany

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Elke Schaffitzel Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany
ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany

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Maren Hertweck Bio 3, Bioinformatics and Molecular Genetics, University of Freiburg, Germany
ZBSA – Freiburg Center for Systems Biology, University of Freiburg, Germany
Renal Division, University Hospital Freiburg, Germany

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negatively regulate the FOXO transcription factor DAF-16. Inhibition of the daf-2 receptor gene expression/activity or other genes in the insulin/IGF pathway can have three effects. (A) Early developmental downregulation, which affects many biological

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Yunshan Hu Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181

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Hong Bin Liu Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181

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Richard W Simpson Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181

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Anthony E Dear Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Department of Diabetes and Endocrinology, Biotechnology Division, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran, Melbourne, Victoria, Australia 3181

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promoter The human and mouse Nur77 promoters share highly conserved binding sites for NF-κB and AP-1 transcription factors ( Pei et al . 2005 ). To define the molecular mechanism of TZD-mediated inhibition of NUR77 expression, we performed EMSAs using

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Botao Du
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Masahide Ohmichi
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Kazuhiro Takahashi
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Jun Kawagoe
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Chika Ohshima
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Hideki Igarashi
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Akiko Mori-Abe
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Maki Saitoh
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Tsuyoshi Ohta
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Akira Ohishi
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Masakazu Doshida
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Naohiro Tezuka
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Toshifumi Takahashi
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Hirohisa Kurachi
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, Meyerson et al. 1997 , Nakamura et al. 1997 ). It was recently reported that TERT protects neurons against Aβ- ( Zhu et al. 2000 ) or tropic factor withdrawal- and glutamate ( Fu et al. 2000 )-induced apoptosis. There is abundant evidence

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David J Mellis Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Cecile Itzstein Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Miep H Helfrich Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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Julie C Crockett Musculoskeletal Research Programme, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB252ZD, UK

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signalling pathways leading to the activation of transcription factors, with the NFκB pathway being of particular importance. The control of osteoclast differentiation and function by signalling pathways is highlighted by conditions in which key components of

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R Wang
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J Li
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N Yashpal
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N Gao
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immunofluorescent staining was performed. There were two sets of co-expression pattern studies. First co-expression of nestin with transcription factors was examined. Co-staining of nestin with PDX-1 was observed at 15±4% in the monolayers after 2 months of culture

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Toshiaki Ishizuka Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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Takashi Hinata Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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Yasuhiro Watanabe Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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mouse MSCs to increase the expression and secretion of VEGF ( Kinnaird et al . 2004 b , Wang et al . 2007 ). Hypoxia-inducible gene transcription is regulated by hypoxia-inducible factor-1 (HIF-1), which is essential for adaptive cellular responses to

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L Bouraoui Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain

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J Gutiérrez Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain

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I Navarro Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain

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(PPARγ) have been identified as transcriptional factors ( MacDougald & Lane 1995 ) and are necessary for the transition of pre-adipocytes into adipocytes in vitro . In mammals, insulin growth factor-I (IGF-I) affects adipocyte proliferation and

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Inga K Johnsen Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Marc Slawik Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Igor Shapiro Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Michaela F Hartmann Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Stefan A Wudy Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Brendan D Looyenga Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Gary D Hammer Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Martin Reincke Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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Felix Beuschlein Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert-Ludwigs-Universität, D-79106 Freiburg, Germany
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Steroid Research Unit, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Germany
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Medizinische Klinik - Innenstadt, Ludwig-Maximilians-University, Munich, Germany

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factors such as GATA-4 ( P = 0.0005), Wilms tumor gene-1 (WT-1; P < 0.0001), and steriodogenic factor-1 (SF-1; P = 0.0029) were significantly up-regulated after GDX, while other transcription factors such as FOG-1 ( P < 0.0001) and GATA-6 ( P = 0

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Susan M Soto Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Amy C Blake Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Stephanie R Wesolowski Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Paul J Rozance Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Kristen B Barthel Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, BioFrontiers Institute, Boulder, Colorado, USA

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Bifeng Gao Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

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Byron Hetrick Department of Human Physiology, University of Oregon, Eugene, Oregon, USA

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Carrie E McCurdy Department of Human Physiology, University of Oregon, Eugene, Oregon, USA

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Natalia G Garza Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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William W Hay Jr Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Leslie A Leinwand Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, BioFrontiers Institute, Boulder, Colorado, USA

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Jacob E Friedman Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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Laura D Brown Department of Pediatrics, University of Colorado School of Medicine, Perinatal Research Center, Aurora, Colorado, USA

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protein 7 (PAX7) denotes a myoblast that has not terminally differentiated and has the capacity to enter the cell cycle and proliferate ( Relaix et al . 2005 ). MRFs are a set of transcription factors, including MYF5 , MYOD , MYF6 and MYOG , that are

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J M P Pabona Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, Arkansas 72202, USA

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M C Velarde Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, Arkansas 72202, USA

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Z Zeng Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, Arkansas 72202, USA

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F A Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, Arkansas 72202, USA

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R C M Simmen Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, Arkansas 72202, USA

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Introduction Estrogen (E) control of cell proliferation is a complex process that is subject to regulation at many levels. The nuclear receptor/transcription factor estrogen receptor-α (ESR1) is the key regulatory participant, transducing E action

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