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Michael Rosenbaum Division of Molecular Genetics, Departments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA

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Rudolph L Leibel Division of Molecular Genetics, Departments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA

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. 2011 ). It should also be clear that leptin does not reverse all of the metabolic and behavioral adaptations that characterize the weight-reduced state. Leptin repletion following weight loss reduces most, but not all, of the hypometabolism and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0358
Volume/Issue:
Volume 223: Issue 1
Free access
M A Hyatt Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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D H Keisler Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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H Budge Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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M E Symonds Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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accompanied by adaptations in its inflammatory and related responses ( Sharkey et al . 2009 b ). We hypothesised that gene expression of key regulators of adipose tissue function and composition would be increased in firstborn offspring during early postnatal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0358
Volume/Issue:
Volume 204: Issue 2
Open access
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Dominique A Glauser Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

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Werner Schlegel Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

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glycemia. Secondly, in the long term, FOXO factors control the adaptation of β cell mass and the ability of the endocrine pancreas to handle future metabolic loads. FOXO in diabetes, a possible therapeutic target

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JOE-06-0191
Volume/Issue:
Volume 193: Issue 2
Free access
Y Feuermann Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
Departments of Animal Science,
Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University School of Medicine, Jerusalem, Israel

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S J Mabjeesh Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
Departments of Animal Science,
Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University School of Medicine, Jerusalem, Israel

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L Niv-Spector Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
Departments of Animal Science,
Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University School of Medicine, Jerusalem, Israel

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D Levin Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
Departments of Animal Science,
Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University School of Medicine, Jerusalem, Israel

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A Shamay Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
Departments of Animal Science,
Biochemistry, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated to the Hebrew University School of Medicine, Jerusalem, Israel

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lactation ( Feuermann et al. 2004 ). Leptin, a protein hormone secreted predominantly by white adipose tissue ( Friedman & Halaas 1998 ), is therefore a key factor in regulating the metabolic adaptation of nutrient partitioning during the energy

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06913
Volume/Issue:
Volume 191: Issue 2
Free access
Benoit Cox Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium

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Heleen Roose Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium

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Annelies Vennekens Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium

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Hugo Vankelecom Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium

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(re-)activated according to the endocrine needs. Adaptation of the cellular composition is observed during puberty (increase in somatotropes) and during pregnancy and lactation (expansion of lactotropes). Mechanisms underlying this pituitary plasticity

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0083
Volume/Issue:
Volume 234: Issue 3
Free access
James S M Cuffe School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia
School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia
Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Zarqa Saif Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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Anthony V Perkins School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia

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Karen M Moritz School of Biomedical Sciences, and Child Health Research Centre, The University of Queensland, St Lucia, Queensland, Australia

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Vicki L Clifton Mater Research Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland, Australia

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glucocorticoid metabolizing enzyme hydroxysteroid 11-β-dehydrogenase isozyme 2 (hsd11b2). These female adaptations likely prevent the cardiovascular and renal dysfunction that develop only in male offspring ( O’Sullivan et al . 2013 ). Normal regulation of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0171
Volume/Issue:
Volume 234: Issue 2
Free access
Melissa A Davis School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Leticia E Camacho School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Alexander L Pendleton School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Andrew T Antolic School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Rosa I Luna-Ramirez School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Amy C Kelly School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Nathan R Steffens School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Miranda J Anderson School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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Sean W Limesand School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

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fetuses. These data demonstrate that the other metabolic features of IUGR, such as low oxygen, glucose, and insulin concentrations, are critical components for metabolic adaptation in glucose fluxes of the IUGR fetus. Adrenergic stimulation has profound

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0071
Volume/Issue:
Volume 249: Issue 3
Restricted access
Neele S Dellschaft Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Marie-Cecile Alexandre-Gouabau Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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David S Gardner Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Jean-Philippe Antignac Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Duane H Keisler Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Helen Budge Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Michael E Symonds Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Sylvain P Sebert Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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-induced IUGR, maternal homeostasis is altered, affecting the metabolic environment in which the fetus develops ( Tygesen et al . 2008 ). It is possible that these metabolic adaptations influence fetal growth independently of changes in the feto

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0600
Volume/Issue:
Volume 224: Issue 2
Free access
Anna Fodor
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Ottó Pintér
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Ágnes Domokos
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Kristina Langnaese Institute of Experimental Medicine, Institut für Biochemie and Zellbiologie, Centre for Behavioral Brain Sciences, Hungarian Academy of Sciences, Szigony 43, 1083 Budapest, Hungary

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István Barna
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Mario Engelmann Institute of Experimental Medicine, Institut für Biochemie and Zellbiologie, Centre for Behavioral Brain Sciences, Hungarian Academy of Sciences, Szigony 43, 1083 Budapest, Hungary
Institute of Experimental Medicine, Institut für Biochemie and Zellbiologie, Centre for Behavioral Brain Sciences, Hungarian Academy of Sciences, Szigony 43, 1083 Budapest, Hungary

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Dóra Zelena
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Introduction Adaptation to stress is a basic phenomenon in mammalian life that is mandatorily associated with the activity of the hypothalamic–pituitary–adrenal (HPA) axis. Extracellular signaling molecules that stimulate the HPA axis at the brain

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0224
Volume/Issue:
Volume 219: Issue 2
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Aline Cordeiro
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Luana Lopes de Souza
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Lorraine Soares Oliveira
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Larissa Costa Faustino
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Letícia Aragão Santiago
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Flavia Fonseca Bloise
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Tania Maria Ortiga-Carvalho
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Norma Aparecida dos Santos Almeida Biophysics Institute Carlos Chagas Filho, Department of Physiological Sciences, Federal University of Rio de Janeiro, Cidade Universitária - Ilha do Fundão, Avenida Carlos Chagas Filho, 373, Centro de Ciências da Saúde, Bloco G, CEP: 21941-902, Rio de Janeiro, RJ, Brazil

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Carmen Cabanelas Pazos-Moura
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. 2008 ). These punctual contributions are extremely valuable to understand the essential role of SIRT1 in adaptation to calorie restriction and fasting, conditions that are able to trigger SIRT1 protein expression in various tissues ( Cohen et al . 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0420
Volume/Issue:
Volume 216: Issue 2
Free access