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Thangiah Geetha Center for Metabolic and Vascular Biology, Department of Pharmaceutical Sciences, Arizona State University, Tempe, Arizona 85287, USA

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Paul Langlais Center for Metabolic and Vascular Biology, Department of Pharmaceutical Sciences, Arizona State University, Tempe, Arizona 85287, USA

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Michael Caruso Center for Metabolic and Vascular Biology, Department of Pharmaceutical Sciences, Arizona State University, Tempe, Arizona 85287, USA

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Zhengping Yi Center for Metabolic and Vascular Biology, Department of Pharmaceutical Sciences, Arizona State University, Tempe, Arizona 85287, USA
Center for Metabolic and Vascular Biology, Department of Pharmaceutical Sciences, Arizona State University, Tempe, Arizona 85287, USA

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MF Kahn CR Benito M 2001 Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis . Molecular and Cellular Biology 21 2269 – 2280 . doi:10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0145
Volume/Issue:
Volume 214: Issue 3
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Samira Fargali Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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Thomas Scherer Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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Andrew C Shin Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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Masato Sadahiro Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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Christoph Buettner Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA
Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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Stephen R Salton Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA
Departments of, Neuroscience, Medicine, Geriatrics, Box 1065, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA

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acclimatisation correlates with brown adipocyte density in mouse adipose organ . Journal of Anatomy 214 171 – 178 . ( doi:10.1111/j.1469-7580.2008.01001.x ) Narkar VA Downes M Yu RT Embler E Wang YX Banayo E Mihaylova MM Nelson MC Zou Y

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DOI:
https://doi.org/10.1530/JOE-12-0172
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Volume 215: Issue 2
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Blerina Kola Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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Márta Korbonits Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

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decreases AMPK activity in adipose tissue (( Kola et al . 2005 ) and Kola & Korbonits unpublished data), while it stimulates it in the hypothalamus. In brown adipocytes, central ghrelin treatment lowered expression of UCP1 and UCP3. Interestingly, the

Article Type:
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DOI:
https://doi.org/10.1677/JOE-09-0056
Volume/Issue:
Volume 202: Issue 2
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Rodrigo Soares Fortunato
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Daniele Leão Ignácio
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Álvaro Souto Padron
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Ramon Peçanha Laboratorio de Fisiologia Endócrina Doris Rosenthal, Laboratório de Cardiologia Celular e Molecular, Laboratório de Biologia Muscular e do Exercício, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro 21941-902, Brazil
Laboratorio de Fisiologia Endócrina Doris Rosenthal, Laboratório de Cardiologia Celular e Molecular, Laboratório de Biologia Muscular e do Exercício, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro 21941-902, Brazil

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Michelle Porto Marassi
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Doris Rosenthal
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João Pedro Saar Werneck-de-Castro Laboratorio de Fisiologia Endócrina Doris Rosenthal, Laboratório de Cardiologia Celular e Molecular, Laboratório de Biologia Muscular e do Exercício, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro 21941-902, Brazil
Laboratorio de Fisiologia Endócrina Doris Rosenthal, Laboratório de Cardiologia Celular e Molecular, Laboratório de Biologia Muscular e do Exercício, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro 21941-902, Brazil

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Denise P Carvalho
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Larsen PR 1987 Catecholamine stimulation of iodothyronine 5′-deiodinase activity in rat dispersed brown adipocytes . Endocrinology 120 1069 – 1072 . Pommier J 1978 Solubilization, purification, propriétés moleculaires et mécanisme d

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DOI:
https://doi.org/10.1677/JOE-08-0174
Volume/Issue:
Volume 198: Issue 2
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Christian Doyon Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Pierre Samson Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Josée Lalonde Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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Denis Richard Chaire de recherche Merck Frosst/IRSC sur l’obésité and Centre de recherche de l’Hôpital Laval, Hôpital Laval, 2725 chemin Sainte-Foy, Québec, Canada G1V 4G5

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of corticotropin releasing factor receptors. PNAS 93 10477 –10482. Sell H , Deshaies Y & Richard D 2004 The brown adipocyte: update on its metabolic role. International Journal of Biochemistry and Cell Biology 36

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DOI:
https://doi.org/10.1677/joe.1.07064
Volume/Issue:
Volume 193: Issue 1
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E E Connor Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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D L Wood Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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T S Sonstegard Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A F da Mota Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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G L Bennett Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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J L Williams Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A V Capuco Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation. Journal of Biological Chemistry 272 31693 –31699. Vega RB , Huss JM & Kelly DP 2000 The coactivator PGC-1 cooperates with peroxisome proliferator

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DOI:
https://doi.org/10.1677/joe.1.06139
Volume/Issue:
Volume 185: Issue 3
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Paolo Comeglio Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Ilaria Cellai Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Tommaso Mello Gastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Sandra Filippi Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of NEUROFARBA, University of Florence, Florence, Italy

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Elena Maneschi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Francesca Corcetto Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Chiara Corno Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Erica Sarchielli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Annamaria Morelli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Elena Rapizzi Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Daniele Bani Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Daniele Guasti Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Gabriella Barbara Vannelli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Andrea Galli Gastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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Luciano Adorini Intercept Pharmaceuticals, New York, New York, USA

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Mario Maggi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy

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Linda Vignozzi Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
Gynecologic Endocrinology Research Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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intracellular cAMP ( Carino et al. 2017 ). TGR5 is generally implicated in the induction of energy expenditure in BAT, reducing in mice diet-induced obesity and insulin resistance ( Watanabe et al. 2006 ). Treatment of human brown adipocytes with BAs or TGR5

Article Type:
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DOI:
https://doi.org/10.1530/JOE-17-0557
Volume/Issue:
Volume 238: Issue 2
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Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Ganesh Panzade Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Rajesh Pandey CSIR Ayurgenomics Unit-TRISUTRA, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Sanchita Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Raj Kumar Mishra SIPS Superspeciality Hospital, Lucknow, India

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Ravi Shankar Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Anil Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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diabetes. Materials and methods hMSC culture and differentiation into white and brown adipocytes Human mesenchymal stem cell (hMSC) was cultured in high-glucose DMEM supplemented with 10% fetal bovine serum (Gibco) and 1% antibiotics. hMSC was

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DOI:
https://doi.org/10.1530/JOE-17-0387
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Volume 239: Issue 1
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Stephanie L Clookey Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Rebecca J Welly Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Terese M Zidon Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Michelle L Gastecki Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Makenzie L Woodford Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Zachary I Grunewald Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Nathan C Winn Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Dusti Eaton Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Natalia G Karasseva Transgenic Animal Core, University of Missouri, Columbia, Missouri, USA

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Harold S Sacks Endocrine and Diabetes Division, Veterans Greater Los Angeles Healthcare System, Los Angeles, California, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Child Health, University of Missouri, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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conditions of this study, BAT phenotype was at most modestly affected based on histological analysis ( Fig. 4A ). UCP1 ablation did increase mean brown adipocyte size (G, P  < 0.05); however, this measure was not affected by OVX ( Fig. 4D ). Analysis of gene

Article Type:
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DOI:
https://doi.org/10.1530/JOE-18-0139
Volume/Issue:
Volume 239: Issue 2
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Xiaoqin Shi Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Xinyu Li Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Yi Hou Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Xuemei Cao Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Yuyao Zhang Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Heng Wang Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Hongyin Wang Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chuan Peng Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Jibin Li Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China

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Qifu Li Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA

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Xiaoqiu Xiao Laboratory of Lipid & Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China

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offspring, we examined BAT histological changes and expression of thermogenic gene UCP1 in STZ-O and CB-O. Figure 4A and B shows histological changes in STZ-O and CB-O rats maintained at 21–22°C (RT). Brown adipocytes from CB-O rats exhibited typically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0082
Volume/Issue:
Volume 234: Issue 2
Free access