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Bernardo Nuche-Berenguer Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Daniel Lozano Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Irene Gutiérrez-Rojas Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Paola Moreno Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Mariñoso Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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Pedro Esbrit Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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María L Villanueva-Peñacarrillo Department of Metabolism, Bone and Mineral Metabolism Laboratory, Department of Pathology, Nutrition and Hormones

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obese subjects ( Zhao et al . 2008 , Buizert et al . 2009 ). It has been reported that the anti-diabetic peptides glucagon-like peptide 1 (GLP-1) and exendin 1–39 amide (Ex-4) show beneficial effects in reducing cholesterol and triglycerides in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0015
Volume/Issue:
Volume 209: Issue 2
Free access
Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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transcribed from the proglucagon gene is processed by the enzyme prohormone convertase 1 and 2 to give glucagon and related peptides including glucagon-like peptide 1 (GLP-1) and oxyntomodulin ( Müller et al. 2017 ). Glucagon regulates glucose, protein and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0365
Volume/Issue:
Volume 261: Issue 3
Open access
Martina Bugáňová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Helena Pelantová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martina Holubová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Šedivá Faculty of Applied Sciences, University of West Bohemia, Plzeň, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Petr Kačer Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Marek Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martin Haluzík Centre for Experimental Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

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( Drucker et al. 2011 , Deacon et al. 2012 ). These therapies include either dipeptidylpeptidase-4 (DPP-4) inhibitors or glucagon-like peptide-1 receptor agonists (GLP-1RAs) ( Brunton 2014 ). DPP-4 inhibitors are presumably a suitable well

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0478
Volume/Issue:
Volume 233: Issue 1
Free access
Shin-ya Ueda Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Takahiro Yoshikawa Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Yoshihiro Katsura Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Tatsuya Usui Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Hayato Nakao Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Shigeo Fujimoto Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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endocrine organs, including ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), and oxyntomodulin ( Huda et al . 2006 , Näslund & Hellstrom 2007 , Wren & Bloom 2007 ). While of these, ghrelin is

Article Type:
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DOI:
https://doi.org/10.1677/JOE-08-0500
Volume/Issue:
Volume 201: Issue 1
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Eun Young Lee
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Shuji Kaneko Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Promsuk Jutabha Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Xilin Zhang
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Susumu Seino Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takahito Jomori Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Naohiko Anzai Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takashi Miki
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Introduction Oral ingestion of nutrients triggers the secretion of gut hormones from various enteroendocrine cells ( Ezcurra et al . 2013 , Cho et al . 2014 ). Among these, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0555
Volume/Issue:
Volume 224: Issue 3
Open access
Kook Hwan Kim Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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Myung-Shik Lee Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea
Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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, nonalcoholic steatohepatitis; HCC, hepatocellular carcinoma; GLP1, glucagon-like peptide 1. The role of stress-induced FGF21 in physiological conditions FGF21 and nutritional status FGF21 expression is regulated by nutritional status, and changes in the FGF21

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0160
Volume/Issue:
Volume 226: Issue 1
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Katrine Dahl Bjørnholm Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark
Department of Cardiovascular Disease Research, Novo Nordisk, Måløv, Denmark

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Gro Klitgaard Povlsen Department of Diabetes Pharmacology 1, Novo Nordisk, Måløv, Denmark

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Maria Elm Ougaard Department of Pathology and Imaging, Novo Nordisk, Måløv, Denmark

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Charles Pyke Department of Pathology and Imaging, Novo Nordisk, Måløv, Denmark

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Günaj Rakipovski Department of Cardiovascular Disease Research, Novo Nordisk, Måløv, Denmark

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Pernille Tveden-Nyborg Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark

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Jens Lykkesfeldt Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark

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Gry Freja Skovsted Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark

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Gaoatswe G Lynch L Corrigan MA Woods C O’Connell J O’Shea D 2014 Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus . Diabetologia 57 781 – 784

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0608
Volume/Issue:
Volume 248: Issue 3
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Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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. 1986 , Rouillé et al. 1994 ). In contrast, PC1/3 is highly enriched in intestinal L cells, where MPGF is further processed into glucagon-like peptide-1 (GLP-1), GLP-2, and oxyntomodulin ( Mojsov et al. 1986 ) ( Fig. 3A ). Figure 3 Glucagon

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Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0298
Volume/Issue:
Volume 258: Issue 1
Free access
Samrin Kagdi Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Sulayman A Lyons Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Jacqueline L Beaudry Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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attractive pharmacotherapy agent for treating type 2 diabetes mellitus (T2DM) and potentially inducing weight loss in obese patients, like glucagon-like peptide-1 receptor (GLP-1R) agonists ( Finan et al. 2016 , Samms et al. 2020 ). In addition, GIPR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0361
Volume/Issue:
Volume 261: Issue 3
Open access
Tao Xie Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

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Min Chen Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

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Lee S Weinstein Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

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. 2003 ). In addition, type 2 diabetics also have increased glucagon (GCG) secretion from pancreatic α-cells and inappropriately increased serum levels of GCG ( Goke 2008 ). Glucagon-like peptide 1 (GLP1) and other incretin hormones promote glucose

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0030
Volume/Issue:
Volume 206: Issue 3
Free access