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Chunyan Zhao and Karin Dahlman-Wright

needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the

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T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

state of enzymes involved in lipogenesis and fatty acid synthesis as well as phosphorylation of the rate-limiting enzyme for lipolysis of hormone sensitive lipase (HSL). Phosphorylation of ATP-citrate lyase (ACL), an enzyme responsible for the synthesis

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Malin Hedengran Faulds, Chunyan Zhao, Karin Dahlman-Wright, and Jan-Åke Gustafsson

lipogenesis/lipolysis Organisms store energy for later use during times of nutrient scarcity. Excess energy is stored as triacylglycerol (TAG) in lipid droplets produced by lipogenesis. When energy is required, TAGs are catabolized into FFAs via lipolytic

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Srilaxmi Kalavalapalli, Fernando Bril, Joy Guingab, Ariana Vergara, Timothy J Garrett, Nishanth E Sunny, and Kenneth Cusi

and lipogenesis, respectively. There was also an amelioration by exenatide administration in the expression of genes linked to inflammation and fibrosis, as indicated by significantly lower mRNA levels of tumor necrosis factor a ( Tnfa ), tissue

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Virginia L Pszczolkowski, Meghan K Connelly, Adam D Beard, Amara D Benn, Jimena Laporta, Laura L Hernandez, and Sebastian I Arriola Apelo

gluconeogenesis, lipolysis, and lipogenesis, among others ( Kim et al. 2010 , Sumara et al. 2012 , Laporta et al. 2013 , Cataldo Bascunan et al. 2019 ). Intravenous 5-HTP infusion into late-lactation dairy cows increased circulating glucose and free

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Liisa Ailanen, Suvi T Ruohonen, Laura H Vähätalo, Katja Tuomainen, Kim Eerola, Henriikka Salomäki-Myftari, Matias Röyttä, Asta Laiho, Markku Ahotupa, Helena Gylling, and Eriika Savontaus

whereby NPY alters energy metabolism have been elucidated in animal models. Central NPY is known to suppress the sympathetic tone, energy expenditure and brown adipose tissue (BAT) thermogenic activity, and to increase lipogenesis in white adipose tissue

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Sheree D Martin and Sean L McGee

& Bruning 2012 ). For example, there is evidence in type 2 diabetes that the ability of insulin to promote hepatic lipogenesis is maintained, despite impairments in insulin-stimulated glycogen synthesis ( Shimomura et al . 2000 ). The nature of this

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Samuel M Lee, Jose Muratalla, Marta Sierra-Cruz, and Jose Cordoba-Chacon

promoter-driven Cre mice show that PPARα controls adipocyte metabolism by reducing lipogenesis, inflammation, and cholesterol ester accumulation to prevent adiposity ( Hinds et al. 2021 ). Another example would be the cardiomyocyte-specific PPARγ

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Laurie Rouger, G Raphaël Denis, Souphalone Luangsay, and Marc Parmentier

. Adipocyte differentiation and activity markers in ChemR23 KO mice The qRT-PCR analysis of WAT markers ( Fig. 5 A) indicated an increased expression of glycerol phosphate dehydrogenase (GPD1), an enzyme involved in lipogenesis, in 14-month-old ChemR23 KO

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Qiong Lv, Rufei Gao, Chuan Peng, Juan Yi, Lulu Liu, Shumin Yang, Danting Li, Jinbo Hu, Ting Luo, Mei Mei, Ying Song, Chaodong Wu, Xiaoqiu Xiao, and Qifu Li

novo lipogenesis, BPA promoted KCs polarization to pro-inflammatory M1 type with increased inflammatory factors, which may also participate in hepatic lipid deposition both in vivo and in vitro . In our study, 5, 50 and 500 µg/kg/day of BPA