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J Kwakkel Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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W M Wiersinga Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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A Boelen Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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. NTI, among others, is characterized by low serum T 3 levels and decreased liver deiodinase type 1 (D1) activity ( Peeters et al. 2003 , Wiersinga 2005 ). It has been shown that proinflammatory cytokines are capable of decreasing liver D1 mRNA

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0177
Volume/Issue:
Volume 194: Issue 2
Free access
Branka Šošić-Jurjević
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Branko Filipović
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Kostja Renko Department of Cytology, Institut für Experimentelle Endokrinologie, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Despot Stefan Boulevard 142, 11000 Belgrade, Serbia

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Vladimir Ajdžanović
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Milica Manojlović-Stojanoski
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Verica Milošević
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Josef Köhrle Department of Cytology, Institut für Experimentelle Endokrinologie, Institute for Biological Research ‘Siniša Stanković’, University of Belgrade, Despot Stefan Boulevard 142, 11000 Belgrade, Serbia

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, environmental, and nutritional factors ( Köhrle 2002 ). DIO1 enzyme activity is mainly regulated by triiodothyronine (T 3 ; Köhrle 1994 ), but sex steroids may also be involved in this regulation. Liver DIO1 activity is higher in young male than in female rats

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0336
Volume/Issue:
Volume 215: Issue 2
Free access
Marco Colella Department of Science and Technology, University of Sannio, Benevento, Italy
IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Valeria Nittoli IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Alfonsina Porciello IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Immacolata Porreca Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK

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Carla Reale IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Filomena Russo IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Nicola Antonino Russo IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Luca Roberto IRGS, Biogem, Ariano Irpino, Avellino, Italy

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Francesco Albano IRGS, Biogem, Ariano Irpino, Avellino, Italy
IEOS-CNR, Naples, Italy

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Mario De Felice IEOS-CNR, Naples, Italy
Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, Naples, Italy

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Massimo Mallardo Molecular Medicine and Medical Biotechnologies, University of Naples ‘Federico II’, Naples, Italy

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Concetta Ambrosino Department of Science and Technology, University of Sannio, Benevento, Italy
IRGS, Biogem, Ariano Irpino, Avellino, Italy
IEOS-CNR, Naples, Italy

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Introduction Thyroid diseases and associated pathologies, such as obesity, non-alcoholic fatty liver disease (NAFLD), and so on, are widespread ( Mehran et al. 2017 ). Genetic and environmental factors contribute to their onset by damaging

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0134
Volume/Issue:
Volume 247: Issue 1
Restricted access
Marcelo A Christoffolete
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Márton Doleschall Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Péter Egri Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Zsolt Liposits Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Ann Marie Zavacki Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Antonio C Bianco Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Balázs Gereben Human and Natural Sciences Center, Laboratory of Endocrine Neurobiology, Division of Endocrinology, Division of Endocrinology, Federal University of ABC, Santo Andre-SP 09210-370, Brazil

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Introduction Thyroid hormone receptor (TR) and liver X-receptors (LXRs) are the key regulators of lipid metabolism. Both these receptors prefer to bind to a direct repeat of the consensus DNA-binding site separated by a 4 bp spacing (DR-4), and thus

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0448
Volume/Issue:
Volume 205: Issue 2
Free access
Maayan Vatarescu The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Sapir Bechor The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Yulia Haim The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tal Pecht The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tanya Tarnovscki The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Noa Slutsky The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Ori Nov The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Hagit Shapiro The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Avishai Shemesh The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Angel Porgador The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Nava Bashan The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Assaf Rudich The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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( Elgazar-Carmon et al . 2008 , Talukdar et al . 2012 ), but already could be tied to insulin resistance, particularly in the liver ( Elgazar-Carmon et al . 2008 , Hadad et al . 2013 ). The secretory profile of adipose tissue is thought to be altered

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0007
Volume/Issue:
Volume 233: Issue 3
Open access
Hong Ma Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Jin Yuan Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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Jinyu Ma Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Jie Ding Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Weiwei Lin Department of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu Province, China

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Xinlei Wang Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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Mingliang Zhang Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Jiangsu Province, China

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Yi Sun Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Runze Wu Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Chun Liu Laboratory Animal Center of Nantong University, Nantong, Jiangsu Province, China

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Cheng Sun Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Yunjuan Gu Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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Introduction Obesity, a global health-threatening pandemic, is often accompanied by high rates of metabolic syndromes and disorders, including endocrine abnormalities, type 2 diabetes (T2D), high blood pressure, and fatty blood and liver

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0693
Volume/Issue:
Volume 243: Issue 2
Restricted access
Lucia Gajdosechova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Katarina Krskova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Ana Belen Segarra Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Andrea Spolcova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Maciej Suski Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Rafal Olszanecki Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Stefan Zorad Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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.4.11.3) is an enzyme that inactivates oxytocin via hydrolysis of the peptide bonds between cysteine and tyrosine ( Rogi et al . 1996 , Keller 2003 , Wallis et al . 2007 ). The liver and kidney have been shown to be responsible for the majority of oxytocin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0417
Volume/Issue:
Volume 220: Issue 3
Free access
Nava Chapnik Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Yoni Genzer Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Avraham Ben-Shimon Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Masha Y Niv Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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Oren Froy Robert H. Smith Faculty of Agriculture, Fritz Haber Center for Molecular Dynamics, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

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). In peripheral tissues, AMPK is phosphorylated and activated under elevated AMP levels by liver kinase B1 (LKB1; Sanders et al . 2007 ) following hormonal signals, such as adiponectin ( Yoon et al . 2006 ). Consequently, activated AMPK

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0625
Volume/Issue:
Volume 221: Issue 1
Free access
Elena Grasselli DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Adriana Voci DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Ilaria Demori DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Canesi DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Rita De Matteis DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Fernando Goglia DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Antonia Lanni DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Gabriella Gallo DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Laura Vergani DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy
DIPTERIS, Dipartimento di Scienze Biomolecolari, Dipartimento di Scienze Biologiche ed Ambientali, Dipartimento di Scienze della Vita, Istituto Nazionale Biostrutture e Biosistemi (INBB), Università di Genova, Genova, Italy

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Introduction Hepatic steatosis refers to an excess accumulation of lipids, primarily triglycerides (TAGs) and it is a major element of non-alcoholic fatty liver disease (NAFLD; Unger et al . 2010 ). Lipid metabolism is mainly regulated by the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0288
Volume/Issue:
Volume 212: Issue 2
Free access
Hamza Amine Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Yacir Benomar Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Adil Haimeur Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Hafida Messaouri Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Nadia Meskini Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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Mohammed Taouis Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France
Unité Mixte de Recherche, Centre National de la Recherche Scientifique, Laboratoire de Virologie, Neuroendocrinolgie Moléculaire de la Prise Alimentaire, NeuroPSI UMR9197, University Paris-Sud, Orsay, France

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, dietary fat plays an important role in the induction of insulin resistance ( Storlien et al . 1997 ). Both the amount and the type of fatty acids ingested alter insulin sensitivity in target tissues (i.e., muscle, adipose tissue and liver) associated with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0316
Volume/Issue:
Volume 228: Issue 1
Free access