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Lihong Fu, Yixuan Qiu, Linyan Shen, Canqi Cui, Shuang Wang, Shujie Wang, Yun Xie, Xinjie Zhao, Xianfu Gao, Guang Ning, Aifang Nie, and Yanyun Gu

Diseases, Ruijin Hospital) for animal care. They are grateful to Dr Qidi Wang and Dr Yifei Zhang (Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital), Dr Hongli Zhang (Department of Endocrine and Metabolic Diseases, The Seventh People

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Ya Pei, Honggui Li, Yuli Cai, Jing Zhou, Xianjun Luo, Linqiang Ma, Kelly McDaniel, Tianshu Zeng, Yanming Chen, Xiaoxian Qian, Yuqing Huo, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Lulu Chen, and Chaodong Wu

Introduction Obesity is an ongoing pandemic and critically contributes to the development and progression of a wide variety of metabolic diseases such as type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular disease. Over the

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Sara S Ellingwood and Alan Cheng

enzymes can lead to metabolic disease. As the primary stores of glycogen are located in liver and muscle tissues, it is not surprising that the GSDs affect one or both of these sites. However, it is fascinating that the symptoms of different GSDs exist in

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Jun-Ping Wen, Chune Liu, Wen-Kai Bi, Ya-Ting Hu, Qingshi Chen, Huibing Huang, Ji-Xing Liang, Lian-Tao Li, Li-Xiang Lin, and Gang Chen

) were provided gratis by Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Jiaotong University School of Medicine (Shanghai, China). GT1-7 cells were maintained in 4.5 g/l glucose DMEM supplemented with 10% fetal bovine serum, 100

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Alberto Loizzo, Santi M Spampinato, Gabriele Campana, Stefano Vella, Andrea Fortuna, Loredana Costa, Anna Capasso, Palmiero Monteleone, Paolo Renzi, and Stefano Loizzo

also on the role played by both systems in stress-related metabolic diseases. Conclusions We demonstrated that the etiopathogenesis of our type 2 diabetes model is connected to postnatal stress in male mice and depends on the break-down of feedback

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Miao Hou, Chenlin Ji, Jing Wang, Yanhua Liu, Bin Sun, Mei Guo, Jonas Burén, and Xiaonan Li

Introduction Obesity, particularly visceral obesity, is related to metabolic diseases such as insulin resistance, hyperlipidemia, hypertension, type 2 diabetes, and nonalcoholic fatty liver disease ( Boden 2011 ). Numerous clinical and experimental

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M J Devlin, C Grasemann, A M Cloutier, L Louis, C Alm, M R Palmert, and M L Bouxsein

maternal nutrition, including the mother's diet during gestation and lactation, can markedly increase the risk of metabolic diseases, such as obesity and type II diabetes ( Ozanne et al . 2004 , Boney et al . 2005 ). The mechanism underlying these

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Alex M DePaoli

further evidence for leptin's potential therapeutic value in metabolic disease. Studies on patients with lipodystrophy were initiated in parallel to the observations of the remarkable effects of leptin in ob/ob patients; these studies in multiple forms

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Jiali Liu, Yue Li, Xiaoyan Zhou, Xi Zhang, Hao Meng, Sanyuan Liu, Lei Zhang, Juntao He, Qian He, and Yan Geng

diabetes. It has been reported that autophagy plays a significant role in regulating insulin sensitivity in obesity and the development of type 2 diabetes. In obese mice, the early inflammatory response in metabolic diseases, such as diabetes and obesity

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Michael Rouse, Antoine Younès, and Josephine M Egan

Introduction Diabetes mellitus (DM) is a chronic metabolic disease that, in 2013, by global estimates has a worldwide prevalence of 382 million people. The number is expected to increase to 592 million by 2035, most having type 2 DM (T2DM