Search Results

You are looking at 81 - 90 of 1,839 items for :

  • Refine by access: All content x
Clear All
Isabel C Greenman Department of Cell Physiology and Pharmacology, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester LE1 9HN, UK

Search for other papers by Isabel C Greenman in
Google Scholar
PubMed
Close
,
Edith Gomez Department of Cell Physiology and Pharmacology, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester LE1 9HN, UK

Search for other papers by Edith Gomez in
Google Scholar
PubMed
Close
,
Claire E J Moore Department of Cell Physiology and Pharmacology, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester LE1 9HN, UK

Search for other papers by Claire E J Moore in
Google Scholar
PubMed
Close
, and
Terence P Herbert Department of Cell Physiology and Pharmacology, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester LE1 9HN, UK

Search for other papers by Terence P Herbert in
Google Scholar
PubMed
Close

revealed that the largest increases in the abundance of polysomal mRNAs encoded proteins associated with oxidative stress, indicating that the expression of these proteins is up-regulated in response to high glucose concentration (Table 2 ). These included

Free access
A. Grossman
Search for other papers by A. Grossman in
Google Scholar
PubMed
Close

Department of Endocrinology, St Bartholomew's Hospital, London ec1a 7be received 16 February 1988 While stress and opiate alkaloids such as morphine have both been with us for millenia, the relationship between the two has remained obstinately enigmatic. The discovery of the endogenous opioid peptides some 13 years ago suggested that we might at last have found the key, but the partners to the relationship, while clearly well disposed to each other, persist in avoiding legal wedlock. Can we not find grounds at least for a prolonged engagement between stress and the opioids in current neuroendocrinology?

Introduction

Circulating opioid peptides

Endorphins

Measurement of circulating opioid peptides has certainly not been encouraging, following the initial euphoria in discovering that certain opioids were indeed present in the peripheral circulation. In man, β-lipotrophin (β-LPH) is co-released with adrenocorticotrophin (ACTH) after cleavage from pro-opiomelanocortin in the corticotrophs of the anterior pituitary,

Restricted access
Bo Qian Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China
Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Bo Qian in
Google Scholar
PubMed
Close
,
Haiyan Wang Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Haiyan Wang in
Google Scholar
PubMed
Close
,
Xiuli Men Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Xiuli Men in
Google Scholar
PubMed
Close
,
Wenjian Zhang Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Wenjian Zhang in
Google Scholar
PubMed
Close
,
Hanqing Cai Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Hanqing Cai in
Google Scholar
PubMed
Close
,
Shiqing Xu Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Shiqing Xu in
Google Scholar
PubMed
Close
,
Yaping Xu Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Yaping Xu in
Google Scholar
PubMed
Close
,
Liya Ye Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Liya Ye in
Google Scholar
PubMed
Close
,
Claes B Wollheim Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Claes B Wollheim in
Google Scholar
PubMed
Close
, and
Jinning Lou Graduate School of Peking Union Medical College, Institute of Clinical Medical Sciences, Department of Cell Physiology and Metabolism, Beijing 100730, People's Republic of China

Search for other papers by Jinning Lou in
Google Scholar
PubMed
Close

Introduction Progressive β-cell failure is the precipitating factor for the transition from the insulin-resistant state to overt type 2 diabetes ( Muoio & Newgard 2008 ). Hyperglycemia and oestrogen receptor (ER) stress have been suggested as

Free access
Nicholas J Bernier Department of Integrative Biology, University of Guelph, 488 Gordon Street, Guelph, Ontario, Canada N1G 2W1

Search for other papers by Nicholas J Bernier in
Google Scholar
PubMed
Close
,
Sarah L Alderman Department of Integrative Biology, University of Guelph, 488 Gordon Street, Guelph, Ontario, Canada N1G 2W1

Search for other papers by Sarah L Alderman in
Google Scholar
PubMed
Close
, and
Erin N Bristow Department of Integrative Biology, University of Guelph, 488 Gordon Street, Guelph, Ontario, Canada N1G 2W1

Search for other papers by Erin N Bristow in
Google Scholar
PubMed
Close

Introduction The corticotropin-releasing factor (CRF) system is a key player in the coordination and regulation of the vertebrate stress response. In teleosts, as in amphibians and mammals, the CRF system is composed of four paralogous lineages of

Free access
Yoon Sin Oh Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Yoon Sin Oh in
Google Scholar
PubMed
Close
,
Youn-Jung Lee Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Youn-Jung Lee in
Google Scholar
PubMed
Close
,
Yup Kang Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Yup Kang in
Google Scholar
PubMed
Close
,
Jaeseok Han Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Jaeseok Han in
Google Scholar
PubMed
Close
,
Oh-Kyung Lim Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Oh-Kyung Lim in
Google Scholar
PubMed
Close
, and
Hee-Sook Jun Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

Search for other papers by Hee-Sook Jun in
Google Scholar
PubMed
Close

. 2004 ). Several potential mechanisms underlying β-cell dysfunction caused by glucolipotoxicity have been suggested, including reactive oxygen species-mediated oxidative stress, inflammatory signals, lipid intermediates, and ER stress ( Donath et al

Free access
Elena Conte Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

Search for other papers by Elena Conte in
Google Scholar
PubMed
Close
,
Adele Romano Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

Search for other papers by Adele Romano in
Google Scholar
PubMed
Close
,
Michela De Bellis Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

Search for other papers by Michela De Bellis in
Google Scholar
PubMed
Close
,
Marialuisa de Ceglia Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

Search for other papers by Marialuisa de Ceglia in
Google Scholar
PubMed
Close
,
Maria Rosaria Carratù Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

Search for other papers by Maria Rosaria Carratù in
Google Scholar
PubMed
Close
,
Silvana Gaetani Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

Search for other papers by Silvana Gaetani in
Google Scholar
PubMed
Close
,
Fatima Maqoud Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

Search for other papers by Fatima Maqoud in
Google Scholar
PubMed
Close
,
Domenico Tricarico Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

Search for other papers by Domenico Tricarico in
Google Scholar
PubMed
Close
, and
Claudia Camerino Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy
Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy
Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

Search for other papers by Claudia Camerino in
Google Scholar
PubMed
Close

-Oxtr vector ( Kasahara et al. 2013 ). We previously demonstrated that Oxt regulates the response to cold stress (CS) in mice through a feed-forward loop in the brain ( Camerino et al. 2017 ). Gene expression analysis shows that mRNA levels of Oxtr are

Restricted access
Ernest Sargsyan
Search for other papers by Ernest Sargsyan in
Google Scholar
PubMed
Close
,
Henrik Ortsäter Department of Medical Cell Biology, Department of Clinical Science and Education, Uppsala University, SE-75123, Uppsala, Sweden

Search for other papers by Henrik Ortsäter in
Google Scholar
PubMed
Close
,
Kristofer Thorn
Search for other papers by Kristofer Thorn in
Google Scholar
PubMed
Close
, and
Peter Bergsten
Search for other papers by Peter Bergsten in
Google Scholar
PubMed
Close

exerts its positive effect have been investigated. In the present study, we wanted to explore whether induction of endoplasmic reticulum (ER) stress ( Wu & Kaufman 2006 ), which has been observed in β-cells exposed to elevated levels of glucose and fatty

Free access
Yolanda Diz-Chaves Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Yolanda Diz-Chaves in
Google Scholar
PubMed
Close
,
Manuel Gil-Lozano Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Manuel Gil-Lozano in
Google Scholar
PubMed
Close
,
Laura Toba Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Laura Toba in
Google Scholar
PubMed
Close
,
Juan Fandiño Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Juan Fandiño in
Google Scholar
PubMed
Close
,
Hugo Ogando Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Hugo Ogando in
Google Scholar
PubMed
Close
,
Lucas C González-Matías Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Lucas C González-Matías in
Google Scholar
PubMed
Close
, and
Federico Mallo Laboratory of Endocrinology, Center for Biomedical Research – CINBIO, University of Vigo, Vigo, Spain
Instituto de Investigación Sanitaria Galicia Sur – IISGS, Vigo, Spain

Search for other papers by Federico Mallo in
Google Scholar
PubMed
Close

Introduction The stress indices in Western societies are correlated with the increasing rates of obesity and metabolic syndrome. Recent data indicate that chronic stress, associated with mild hypercortisolaemia and prolonged sympathetic

Free access
W. S. BULLOUGH
Search for other papers by W. S. BULLOUGH in
Google Scholar
PubMed
Close

The effects of stress, induced by overcrowding adult male mice, have been examined in relation to adrenal size and to epidermal mitotic activity. After 3 weeks the size (expressed as the maximum sectional area) of the adrenal medulla of the crowded mice increased by about 80 %, while that of the cortex increased by about 30 %. Simultaneously, the epidermal mitotic rate fell by about 60 %.

The effects of the adrenal hormones on epidermal mitosis were next studied. It was found that adrenaline has a powerful antimitotic action both in vivo and in vitro, and that the same is true of the glucocorticoid hormone, 11-dehydro-17-hydroxycorticosterone-21-acetate (cortisone).

It is suggested that the antimitotic effects of stress may be due to a high rate of secretion of either, or both, these adrenal hormones, and that these substances act through some interference in carbohydrate metabolism. When energy production is inhibited, it is known that, while no new epidermal mitosis can develop, there is no impediment to the completion of any division already in progress, and this is the precise pattern of inhibition produced by both adrenaline and cortisone.

Evidence is reviewed to suggest that the antimitotic action of these hormones may be related to an inhibition of hexokinase. Adrenaline is not known to affect this enzyme, but it is rapidly oxidized to adrenochrome which does. It is shown that adrenochrome has a powerful antimitotic action.

Restricted access
C Doyon Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada

Search for other papers by C Doyon in
Google Scholar
PubMed
Close
,
V L Trudeau Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada

Search for other papers by V L Trudeau in
Google Scholar
PubMed
Close
, and
T W Moon Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada

Search for other papers by T W Moon in
Google Scholar
PubMed
Close

Introduction The primary stress response involves the activation of hypothalamic neurons producing corticotropin-releasing factor (CRF), an initial step in the cascade that leads to the synthesis and release of glucocorticoids

Free access