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Ana B Ropero, Pablo Juan-Picó, Alex Rafacho, Esther Fuentes, F Javier Bermúdez-Silva, Enrique Roche, Ivan Quesada, Fernando Rodríguez de Fonseca, and Angel Nadal

superfamily of ligand activated transcription factors ( Robinson-Rechavi et al . 2003 ). PPARs, particularly PPARα and γ, are regulators of lipid metabolism because they act as lipid sensors. Therefore, PPAR ligands represent important pharmaceutical agents

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B Shan, C Schaaf, A Schmidt, K Lucia, M Buchfelder, M Losa, D Kuhlen, J Kreutzer, M J Perone, E Arzt, G K Stalla, and U Renner

), the regulated subunit of the transcription factor HIF1 ( Harris 2002 , Hickey & Simon 2006 ). The latter is composed of two subunits, the constitutively expressed HIF1B and HIF1A, which is absent under normoxic conditions but is rapidly up

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Esther Dos Santos, Marie-Noëlle Dieudonné, Marie-Christine Leneveu, René Pecquery, Valérie Serazin, and Yves Giudicelli

the phospholipase A2 in the cytoplasm and several transcription factors in the nucleus like the proto-oncogene c-fos ( Janknecht et al. 1995 ), which plays a pivotal role in preadipocyte growth induction ( Lacasa et al. 1997 a , b ). The

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Masaya Takeda, Fumio Otsuka, Hiroyuki Otani, Kenichi Inagaki, Tomoko Miyoshi, Jiro Suzuki, Yukari Mimura, Toshio Ogura, and Hirofumi Makino

implicated it in processes of inflammation, atherosclerosis, cell cycle control, apoptosis, and carcinogenesis ( Auwerx 1999 ). PPARs act as a transcription factor when heterodimerized with the retinoid X receptor and bound to the proper ligands, including

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Lori Cole, Miranda Anderson, Parker B Antin, and Sean W Limesand

transcription factors involved in endocrine cell determination from pluripotent pancreatic progenitors has been established ( Jensen 2004 ). Using this knowledge, we determined PDX1 , NGN3 , and Nkx homeobox proteins, NKX2.2 and NKX6.1 , expression in sheep

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Aowen Zhuang and Josephine M Forbes

pathways, activated by transmembrane sensors located in the ER membrane. These three major pathways are the inositol-requiring protein 1 (IRE1), activating transcription factor 6 (ATF6) and the PKR-like ER kinase (PERK)-mediated response. When protein

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Bo Chen, Yanrong Lu, Younan Chen, and Jingqiu Cheng

activity is disrupted, it is no longer possible to maintain appropriate redox balance. Nuclear factor-E2-related factor 2 (Nrf2), a transcription factor with a high sensitivity to oxidative stress, binds to antioxidant response elements (AREs) in the

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Robert Opitz, Achim Trubiroha, Claudia Lorenz, Ilka Lutz, Sabine Hartmann, Tobias Blank, Thomas Braunbeck, and Werner Kloas

( Saito et al. 1997 a , Ohno et al. 1999 , Trapasso et al. 1999 ). Three different transcription factors, including the paired box gene Pax8, the homeo-domain-containing protein Nkx2.1 (also called TTF-1 for thyroid transcription factor 1) and the

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A Fratticci, F A Grieco, C Spilioti, F Giangaspero, L Ventura, V Esposito, M Piccirilli, A Santoro, A Gulino, G Cantore, E Alesse, and M L Jaffrain-Rea

Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and

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Yujiao Dai, Peng Hao, Zhimei Sun, Zhiyi Guo, Hong Xu, Lihui Xue, Hongyu Song, Yida Li, Shuang Li, Mingming Gao, Teng Si, Yuxin Zhang, and Yajuan Qi

potentially reverse hepatic fibrosis ( Mannaerts et al. 2015 ). As a coactivator of transcription factors, YAP promotes cell proliferation and inhibits apoptosis through the interaction between its transcriptional coactivator activity and TEAD