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superfamily of ligand activated transcription factors ( Robinson-Rechavi et al . 2003 ). PPARs, particularly PPARα and γ, are regulators of lipid metabolism because they act as lipid sensors. Therefore, PPAR ligands represent important pharmaceutical agents

), the regulated subunit of the transcription factor HIF1 ( Harris 2002 , Hickey & Simon 2006 ). The latter is composed of two subunits, the constitutively expressed HIF1B and HIF1A, which is absent under normoxic conditions but is rapidly up

the phospholipase A2 in the cytoplasm and several transcription factors in the nucleus like the proto-oncogene c-fos ( Janknecht et al. 1995 ), which plays a pivotal role in preadipocyte growth induction ( Lacasa et al. 1997 a , b ). The

implicated it in processes of inflammation, atherosclerosis, cell cycle control, apoptosis, and carcinogenesis ( Auwerx 1999 ). PPARs act as a transcription factor when heterodimerized with the retinoid X receptor and bound to the proper ligands, including

transcription factors involved in endocrine cell determination from pluripotent pancreatic progenitors has been established ( Jensen 2004 ). Using this knowledge, we determined PDX1 , NGN3 , and Nkx homeobox proteins, NKX2.2 and NKX6.1 , expression in sheep

pathways, activated by transmembrane sensors located in the ER membrane. These three major pathways are the inositol-requiring protein 1 (IRE1), activating transcription factor 6 (ATF6) and the PKR-like ER kinase (PERK)-mediated response. When protein

activity is disrupted, it is no longer possible to maintain appropriate redox balance. Nuclear factor-E2-related factor 2 (Nrf2), a transcription factor with a high sensitivity to oxidative stress, binds to antioxidant response elements (AREs) in the

( Saito et al. 1997 a , Ohno et al. 1999 , Trapasso et al. 1999 ). Three different transcription factors, including the paired box gene Pax8, the homeo-domain-containing protein Nkx2.1 (also called TTF-1 for thyroid transcription factor 1) and the

Introduction Basic helix-loop-helix (bHLH) transcription factors play a fundamental role in the ontogenesis of highly differentiated cells, especially during neurogenesis, myogenesis and haemopoiesis ( Massari & Murre 2000 ), and

potentially reverse hepatic fibrosis ( Mannaerts et al. 2015 ). As a coactivator of transcription factors, YAP promotes cell proliferation and inhibits apoptosis through the interaction between its transcriptional coactivator activity and TEAD