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Li Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Xiaohua Li Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Wenjun Zhou Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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Joseph L Messina Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA
Department of Psychiatry and Behavioral Neurobiology, St Vincent Health System, Department of Animal Sciences, Division of Molecular and Cellular Pathology, Veterans Affairs Medical Center, The University of Alabama at Birmingham, 1720 University Boulevard, Birmingham, Alabama 35294, USA

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). The protein concentrations of tissue lysates were determined by the BCA method (Pierce, Rockford, IL, USA). For immunoblotting, protein was separated by SDS–PAGE and analyzed by specific antibodies including anti-phosphothreonine 308-AKT, anti

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0559
Volume/Issue:
Volume 217: Issue 2
Free access
Márcio Pereira-da-Silva Department of Internal Medicine, State University of Campinas, Brazil

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Cláudio T De Souza Department of Internal Medicine, State University of Campinas, Brazil

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Alessandra L Gasparetti Department of Internal Medicine, State University of Campinas, Brazil

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Mário J A Saad Department of Internal Medicine, State University of Campinas, Brazil

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Lício A Velloso Department of Internal Medicine, State University of Campinas, Brazil

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-pERK (αpERK/Tyr 204, detecting pERK42 and pERK44), anti-Akt1, and anti-phospho [Ser 473 ]Akt1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Rabbit anti-p85/phosphatidylinositol-3 kinase (PI3-kinase) antiserum was from UBI (Lake Placid, NY, USA

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06111
Volume/Issue:
Volume 186: Issue 1
Free access
Te Du Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Liu Yang Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Xu Xu School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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Xiaofan Shi Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Xin Xu Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Jian Lu School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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Jianlu Lv School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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Xi Huang School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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Jing Chen Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Heyao Wang Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

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Jiming Ye School of Health and Biomedical Sciences, RMIT University, Victoria, Australia

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Lihong Hu School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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Xu Shen Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China
School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China

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-coupled receptors, Akt, IRS2, PTEN, Fas/FasL, NF-κb, Bcl2 family, caspase family, ion channels and so on are tightly associated with β-cell apoptosis ( Anuradha et al . 2014 , Reimann & Gribble 2016 ), and some of the β-cell apoptosis-related proteins have been

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0432
Volume/Issue:
Volume 240: Issue 2
Free access
Patrícia Oliveira Prada Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Michella Soares Coelho Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Henrique Gottardello Zecchin Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Miriam Sterman Dolnikoff Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Alessandra Lia Gasparetti Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Luzia Naôko Shinohara Furukawa Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Mario José Abdalla Saad Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Joel Claudio Heimann Departamento de Clínica Médica da Universidade Estadual de Campinas, Campinas, Brazil
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
Departamento de Clínica Médica, Divisão de Nefrologia, Laboratório de Hipertensão Experimental da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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2002 ). Following tyrosine phosphorylation, IRS-1 and IRS-2 bind and activate the enzyme phosphatidylinositol 3-kinase (PI3-K) ( Folli et al. 1992 , Saltiel & Pessin 2002 ). The activation of PI3-K increases serine phosphorylation of Akt (protein

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06028
Volume/Issue:
Volume 185: Issue 3
Free access
Ida Alenkvist Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Oleg Dyachok Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Geng Tian Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Jia Li Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Saba Mehrabanfar Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Yang Jin Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Bryndis Birnir Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Anders Tengholm Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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Michael Welsh Department of Medical Cell Biology, Department of Neuroscience, Uppsala University, Box 571, Husargatan 3, 75123 Uppsala, Sweden

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FAK activity, which in turn acts as a scaffold in focal adhesions and activates various downstream signaling pathways, such as AKT and ERK ( Parsons 2003 ). In β-cells, FAK has been shown to convey signals from the extracellular matrix ( Hammar et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0531
Volume/Issue:
Volume 223: Issue 3
Free access
Sattar Gorgani-Firuzjaee Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

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Salar Bakhtiyari Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

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Abolfazl Golestani Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

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Reza Meshkani Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
Department of Biochemistry, Department of Clinical Biochemistry, Endocrinology and Metabolism Research Centre, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

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carried out through overnight incubation at 4 °C with 5% nonfat dry milk in TBS with 0.5% Tween 20. Blots were incubated with antibodies against LAR, p-IRS1 (Tyr632), and IRS1 (Santa Cruz Biotechnology); Akt and phospho-Akt (Ser473) (Cell Signaling

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0160
Volume/Issue:
Volume 215: Issue 1
Free access
Hikari Hirakida Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Taiga Okumura Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Ryosuke Fujita Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Yoshiki Kuse Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Takahiro Mizoguchi Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Satoshi Inagaki Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Shinsuke Nakamura Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

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Masamitsu Shimazawa Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
Lab. of Collaborative Research for Innovative Drug Discovery, Gifu Pharmaceutical University, Gifu, Japan

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Hideaki Hara Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
Lab. of Collaborative Research for Innovative Drug Discovery, Gifu Pharmaceutical University, Gifu, Japan

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:1000; Santa Cruz Biotechnology, catalogue sc-365397), mouse anti-β-actin (1:2000; Sigma-Aldrich, catalogue A2228), rabbit anti-phospho-Akt (1:1000; Cell Signaling, catalogue 4058), rabbit anti-total-Akt (1:1000; Cell Signaling, catalogue 9272), rabbit anti

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0267
Volume/Issue:
Volume 257: Issue 3
Restricted access
Kai Wang
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Jing Zheng Clinical and Translational Research Center, Perinatal Research Laboratories, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China

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specific receptors that have cytoplasmic tyrosine kinase domains. Upon activation, these receptor-tyrosine kinases initiate a cascade of cellular protein phosphorylation by protein kinases (PKs), including ERK1/2, AKT1, and p38 MAPK ( Cobb 1999 , Boilly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0296
Volume/Issue:
Volume 212: Issue 3
Free access
AnneMarie Gagnon Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9

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Anne Landry Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9

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Alexander Sorisky Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
Chronic Disease Program, Departments of Medicine and of Biochemistry, Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9

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a nitrocellulose membrane. Non-specific binding sites were blocked and membranes were incubated with antibodies specific for actin (0.4 μg/ml; Santa Cruz Biotech., Santa Cruz, CA, USA), AKT (clone C-20; 2 μg/ml; Santa Cruz Biotech.), fatty acid

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0411
Volume/Issue:
Volume 201: Issue 1
Free access
Ewa Ocłoń Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland

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Anna Latacz Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland

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Joanna Zubel–Łojek Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland

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Krystyna Pierzchała–Koziec Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland

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. miRNAs Significant pathways P -value Target genes mir-144-3p miR-675-5p miR-193a-3p Insulin signaling pathway (04910) 0.006 GSK3B, SOS2, CALM1, SOCS2, PIK3CB, PPP1CC, PCK2, KRAS, TSC2, EIF4E, MAPK8, PRKX, PRKAA1, AKT3, MTOR miR

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0495
Volume/Issue:
Volume 229: Issue 3
Free access