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Maria Esteban-Lopez Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Miami, Florida, USA

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Alexander I Agoulnik Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Miami, Florida, USA
Biomolecular Science Institute, Florida International University, Miami, Florida, USA

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developmental pathways and drives morphogenetic changes in gubernaculum ( Johnson et al. 2010 ). It was shown that Rxfp2 −/− male mice embryos experienced a dramatic decrease in expression of developmental signaling molecules β-catenin, NOTCH1, and WNT1 in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0168
Volume/Issue:
Volume 247: Issue 1
Free access
Richard C Lindsey Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA

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Catrina Godwin Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA

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Subburaman Mohan Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, California, USA
Center for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA
Department of Orthopedics, School of Medicine, Loma Linda University, Loma Linda, California, USA

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, affects millions worldwide ( Drake & Khosla 2019 ). Despite the existence of current therapies, the economic and health burden of osteoporosis is expected to rise, suggesting an urgent need for a more complete understanding of the molecular pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0172
Volume/Issue:
Volume 242: Issue 3
Free access
Lei Du State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yang Wang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Cong-Rong Li State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Liang-Jian Chen State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Jin-Yang Cai State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Zheng-Rong Xia Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Wen-Tao Zeng Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Zi-Bin Wang Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Xi-Chen Chen Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Fan Hu State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Dong Zhang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Xiao-Wei Xing The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhi-Xia Yang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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performed western blotting analysis of p-AKT, p-RPS6, and p-AMPK, the components of the mTOR signaling pathway essential for the survival or activation of the primordial follicles. Low p-AKT and p-RPS6 levels and high p-AMPK levels usually suggest that more

Article Type:
Research Article
Collections:
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DOI:
https://doi.org/10.1530/JOE-20-0068
Volume/Issue:
Volume 248: Issue 2
Restricted access
Karla J Suchacki The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Fiona Roberts The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

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Andrea Lovdel The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Colin Farquharson The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

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Nik M Morton The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Vicky E MacRae The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

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William P Cawthorn The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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-associated proteins act as a bridge to link complex pathways that bring together bone turnover, mineralisation, mineral and metabolic homeostasis. When these pathways become dysregulated, affected individuals may suffer from bone, muscle and adipose pathology ( Fig. 2

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0147
Volume/Issue:
Volume 234: Issue 1
Free access
Yin Xia
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Alan L Schneyer Program in Membrane Biology and Division of Nephrology, Pioneer Valley Life Science Institute and University of Massachusetts-Amherst, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA

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Keller GM Gadue P 2008 Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood . Cell Stem Cell 2 60 – 71 . Ogawa K Abe K Kurosawa N Kurohmaru M Sugino H Takahashi M

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0549
Volume/Issue:
Volume 202: Issue 1
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Ying-Ying Tsai Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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William E Rainey Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Wendy B Bollag Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA

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increased expression of the VLDL receptor ( Liu et al . 2009 ). Additionally, VLDL appears to be a negative regulator of the Wnt pathway in endothelial cells, in which selective knockdown of its receptor resulted in the upregulation of low

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0237
Volume/Issue:
Volume 232: Issue 2
Free access
Juliano C da Silveira Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil

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Ana Clara F C M de Ávila Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil

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Hannah L Garrett Department of Biomedical Sciences, College of Veterinary and Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado, USA

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Jason E Bruemmer Department of Biomedical Sciences, College of Veterinary and Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado, USA

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Quinton A Winger Department of Biomedical Sciences, College of Veterinary and Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado, USA

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Gerrit J Bouma Department of Biomedical Sciences, College of Veterinary and Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado, USA

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members of the WNT and TGFβ signaling pathways, well-known regulatory pathway of folliculogenesis ( Van Den Hurk & Zhao 2005 , Knight & Glister 2006 , da Silveira et al. 2012 ). EVs mediated delivery of molecular cargo between the different follicular

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0200
Volume/Issue:
Volume 236: Issue 1
Free access
Lu Fu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China


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Hongyuan Zhang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China


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Jeremiah Ong’achwa Machuki Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Tingting Zhang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lin Han Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lili Sang Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Lijuan Wu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Zhiwei Zhao Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China
Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Matthew James Turley National Heart and Lung Institute, Imperial College London, UK

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Xide Hu Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Hongjian Hou Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Dongye Li Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, Jiangsu, China

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Sian E Harding National Heart and Lung Institute, Imperial College London, UK

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Hong Sun Physiology Department, Xuzhou Medical University, Xuzhou, Jiangsu, China

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-4) (WiCell Research Institute) were differentiated into cardiomyocytes using small-molecule modulation of the Wnt/β-catenin pathway based on previous protocols ( Lian et al. 2013 , Burridge et al. 2014 ). Cells were cultured in RPMI 1640/1x B27 with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0451
Volume/Issue:
Volume 249: Issue 3
Restricted access
Jorge N Artaza Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA
Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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Rajan Singh Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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Monica G Ferrini Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA
Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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Melissa Braga Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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James Tsao Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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Nestor F Gonzalez-Cadavid Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA
Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, Department of Biomedical Sciences, The Charles R Drew University of Medicine and Science, Department of Urology, UCLA David Geffen School of Medicine, 1731 East 120th Street, Los Angeles, California, 90059, USA

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factor. They also share the downstream Smad signaling pathway. Smad3 is a well-known profibrotic agent, more than Smad2, whereas Smad6 and 7 are antifibrotic, similar to another upstream member of the TGF-β1 family, bone morphogenic protein 7 (BMP-7

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0408
Volume/Issue:
Volume 196: Issue 2
Free access
Hyunju Chung
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Endan Li Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Yumi Kim Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Sehee Kim Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Seungjoon Park Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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restored the numbers of progenitor cells to those of the wild-type controls. In addition, it has been reported that ghrelin increases the cellular proliferation of cultured adult rat hippocampal progenitor cells through the activation of MAPK pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0045
Volume/Issue:
Volume 218: Issue 1
Free access