). Triglycerides are a major energy source and the predominant form of energy storage in several cell types, together with fatty acids, normally stored as lipid droplets in ovarian cells ( Wu et al. 2010 ). Fatty acid and glucose oxidation provide energy
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Giselle Adriana Abruzzese, Maria Florencia Heber, Silvana Rocío Ferreira, María José Ferrer, and Alicia Beatriz Motta
Giselle Adriana Abruzzese, Maria Florencia Heber, Silvana Rocio Ferreira, Leandro Martin Velez, Roxana Reynoso, Omar Pedro Pignataro, and Alicia Beatriz Motta
are many hypotheses about its origin ( Yasui et al . 2012 , Lee et al . 2014 ). Currently, the most accepted model proposes a multiple and parallel hits hypothesis. Fatty acids and their metabolites are the lipotoxic agents involved in NAFLD
Sihan Lv, Xinchen Qiu, Jian Li, Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang, and Bing Luan
& Karin 2012 ). Disrupted lipid metabolism including fatty acid oxidation and de novo lipogenesis in liver results in the development of hepatic steatosis and contributes to the development of hepatic insulin resistance ( Marchesini et al . 2003
A Hourvitz, E Gershon, J D Hennebold, S Elizur, E Maman, C Brendle, E Y Adashi, and N Dekel
of these genes, those encoding C-FABP (cutaneous fatty acid-binding protein), the interleukin-4 receptor alpha chain, and preponociceptin, were validated by Northern blot hybridization analysis and further characterized. Taken together, these
Sung-Soo Park, Yeon-Joo Lee, Sooyeon Song, Boyong Kim, Hyuno Kang, Sejong Oh, and Eungseok Kim
unexplored. The liver plays a key role in whole-body energy homeostasis by regulating lipogenesis and fatty acid oxidation ( Reddy & Rao 2006 ). A large body of evidence has shown that two transcription factors, sterol regulatory element-binding protein 1c
Caitlin S Wyrwoll, Peter J Mark, Trevor A Mori, and Brendan J Waddell
& Kelly 2006 ), whereas UCP3 promotes fatty acid oxidation ( MacLellan et al . 2005 ) and glucose uptake ( Huppertz et al . 2001 ), and limits mitochondrial damage via effects on lipid peroxidation ( Brand et al . 2002 ). The interactive effects of a
Sandra Zárate, Mariana Astiz, Natalia Magnani, Mercedes Imsen, Florencia Merino, Silvia Álvarez, Analía Reinés, and Adriana Seilicovich
, mostly composed of phospholipids, are main targets of oxidative damage due to their physicochemical properties and the chemical reactivity of their fatty acid (FA) double bonds ( Pamplona 2008 , Paradies et al. 2011 ). In fact, membrane phospholipid
Melanie Tran, Golam Mostofa, Michael Picard, Jianguo Wu, Li Wang, and Dong-Ju Shin
timepoints 0, 5, 10, 15, 30, and 60 min after the 6 h fasting period, then cell lysates were collected for immunoblotting analyses. Biochemical analysis Fatty acid oxidation (FAO) enzyme activity was measured in livers of HFHS-fed mice using a
Liisa Ailanen, Suvi T Ruohonen, Laura H Vähätalo, Katja Tuomainen, Kim Eerola, Henriikka Salomäki-Myftari, Matias Röyttä, Asta Laiho, Markku Ahotupa, Helena Gylling, and Eriika Savontaus
contribute to hepatic lipogenesis, VLDL-triglyceride (TG) and VLDL-cholesterol secretion, fatty acid (FA) oxidation and increased serum cholesterol levels (Zarjevski et al. 1993, Stafford et al. 2008, Zhang et al. 2010, Bruinstroop et al. 2012, Xie
Lihong Fu, Yixuan Qiu, Linyan Shen, Canqi Cui, Shuang Wang, Shujie Wang, Yun Xie, Xinjie Zhao, Xianfu Gao, Guang Ning, Aifang Nie, and Yanyun Gu
. The taxa changed after transient abx treatment include those short-chain fatty acids (SCFAs) producers and/or bile acids (BAs) convertors, hereafter, the transient abx treatment also disturbs the production of these main bacteria metabolites ( Jiang
