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Christian Hölscher Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, UK

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Introduction The main hallmark of type 2 diabetes mellitus (T2DM) is insulin desensitisation. The discovery that the incretin hormone glucagon-like peptide 1 (GLP-1) facilitates insulin release during episodes of hyperglycaemia and has several

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0221
Volume/Issue:
Volume 221: Issue 1
Free access
Qiaoli Cui Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Yijing Liao Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Yaojing Jiang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Xiaohang Huang Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Weihong Tao Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Quanquan Zhou Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Anna Shao Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

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Ying Zhao Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Jia Li Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Anran Ma Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Zhihong Wang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Li Zhang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China

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Zunyuan Yang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Yinan Liang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Minglin Wu Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Zhenyan Yang Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Wen Zeng Primed Non-Human Primate Research Centre (Sichuan Primed Shines Bio-tech Co., Ltd.), Chengdu, Sichuan, China

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Qinghua Wang Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China
Keenan Research Centre for Biomedical Science, Division of Endocrinology and Metabolism, St. Michael’s Hospital, Toronto, Ontario, Canada

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Introduction Glucagon-like peptide 1 (GLP-1) is an incretin hormone produced and secreted by intestinal L cells in response to nutrients ingestion. GLP-1 regulates glucose metabolism mainly by stimulating postprandial insulin secretion and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0255
Volume/Issue:
Volume 248: Issue 2
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Akiko Mizokami OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

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Satoru Mukai OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

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Jing Gao Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

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Tomoyo Kawakubo-Yasukochi Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

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Takahito Otani Division of Functional Structure, Department of Morphological Biology, School of Dental Medicine, Fukuoka Dental College, Fukuoka, Japan

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Hiroshi Takeuchi Division of Applied Pharmacology, Kyushu Dental University, Kitakyushu, Japan

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Eijiro Jimi OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

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Masato Hirata Oral Medicine Research Center, School of Dental Medicine, Fukuoka Dental College, Fukuoka, Japan

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et al. 2014 ) or indirectly through stimulation of the secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells ( Mizokami et al. 2013 , 2014 ). GLP-1 is a member of the incretin family of hormones that are secreted from

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0288
Volume/Issue:
Volume 244: Issue 2
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Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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disadvantageous regulatory mechanisms in a cell-targeted, pathophysiology-specific manner. This review aims to outline the current understanding of signaling bias at the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) in three broad categories: (i) ligand

Article Type:
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Collections:
Incretins
DOI:
https://doi.org/10.1530/JOE-23-0226
Volume/Issue:
Volume 261: Issue 2
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Shin-ya Ueda Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Takahiro Yoshikawa Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Yoshihiro Katsura Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Tatsuya Usui Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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Shigeo Fujimoto Department of Sports Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan

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number of gastrointestinal hormones, such as peptide YY (PYY) and glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO Database; Huda et al . 2006 , Näslund & Hellström 2007 , Wren & Bloom 2007 ). PYY is recognized as a satiety factor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0190
Volume/Issue:
Volume 203: Issue 3
Free access
Carmen Sanz Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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Isabel Roncero Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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Patricia Vázquez Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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M Angeles Navas Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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Enrique Blázquez Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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glucose concentrations and peptides on GK gene promoter expression was tested in transiently transfected GT1-7 cells. Neither different glucose concentrations (2.8, 5.5, 10, or 20 mM) nor leptin (LEP), glucagon-like peptide 1 (GLP-1) or neuropeptide Y

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0146
Volume/Issue:
Volume 193: Issue 2
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Benjamin J Lamont Department of Medicine (Austin Health), The University of Melbourne, Melbourne, Victoria, Australia

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Sofianos Andrikopoulos Department of Medicine (Austin Health), The University of Melbourne, Melbourne, Victoria, Australia

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Introduction The incretins glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) act via specific G-protein-coupled receptors to potentiate insulin secretion from pancreatic β-cells in a glucose-dependent manner

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0577
Volume/Issue:
Volume 221: Issue 1
Free access
Yoon Sin Oh Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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Youn-Jung Lee Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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Yup Kang Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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Jaeseok Han Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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Oh-Kyung Lim Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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Hee-Sook Jun Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea
Lee Gil Ya Cancer and Diabetes Institute, Department of Endocrinology and Metabolism, Howard Hughes Medical Institute, Gachon Medical Research Institute, Department of Rehabilitation Medicine, College of Pharmacy, Gachon University, 7-45 Songdo‐dong, Yeonsu‐ku, Incheon, Korea

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-cells and diabetes mellitus . Experimental Biology and Medicine 228 1213 – 1217 . Cunha DA Ladriere L Ortis F Igoillo-Esteve M Gurzov EN Lupi R Marchetti P Eizirik DL Cnop M 2009 Glucagon-like peptide-1 agonists protect pancreatic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0311
Volume/Issue:
Volume 216: Issue 3
Free access
Mohamed Lotfy Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Jaipaul Singh Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates
Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Hameed Rashed Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Saeed Tariq Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Erika Zilahi Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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Ernest Adeghate Department of Biology, School of Forensic and Investigative Sciences, Hormones Department, School of Pharmacy and Biomedical Sciences, Anatomy, Medical Microbiology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates

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endocrine and an exocrine system with much interaction between the two parts ( Shetzline & Liddle 2002 ). The GI tract secretes a number of hormones including glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP1; Drucker 2003 b

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0426
Volume/Issue:
Volume 220: Issue 3
Free access
Eun Young Lee
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Shuji Kaneko Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Promsuk Jutabha Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Xilin Zhang
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Susumu Seino Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takahito Jomori Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Naohiko Anzai Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takashi Miki
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Introduction Oral ingestion of nutrients triggers the secretion of gut hormones from various enteroendocrine cells ( Ezcurra et al . 2013 , Cho et al . 2014 ). Among these, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0555
Volume/Issue:
Volume 224: Issue 3
Open access