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Bethany P Cummings
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Ahmed Bettaieb Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

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James L Graham Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

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Kimber Stanhope Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

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Fawaz G Haj Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

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Peter J Havel Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA

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triglyceride (TG) concentrations ( P <0.001; Fig. 4 A, B and C). Enzymes involved in the regulation of fatty acid oxidation and lipogenesis were measured in subcutaneous WAT and BAT by immunoblotting in order to perform an initial investigation of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0601
Volume/Issue:
Volume 221: Issue 1
Free access
Bel M Galmés-Pascual Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Antonia Nadal-Casellas Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain

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Marco Bauza-Thorbrügge Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Miquel Sbert-Roig Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain

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Francisco J García-Palmer Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Ana M Proenza Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Magdalena Gianotti Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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Isabel Lladó Departament de Biologia Fonamental i Ciències de la Salut, Grup Metabolisme Energètic i Nutrició, Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain

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above in combination with increased lipogenesis, such as the higher Srebp1c mRNA levels shown, caused hepatic triglyceride accumulation. In contrast, E2 replacement ameliorated mitochondrial function and biogenesis of OVX rats, accompanied by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0350
Volume/Issue:
Volume 232: Issue 2
Free access
Virginia L Pszczolkowski Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Meghan K Connelly Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Vita Plus Corporation, Madison, Wisconsin, USA

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Adam D Beard Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Amara D Benn Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA

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Jimena Laporta Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Laura L Hernandez Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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Sebastian I Arriola Apelo Department of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA

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gluconeogenesis, lipolysis, and lipogenesis, among others ( Kim et al. 2010 , Sumara et al. 2012 , Laporta et al. 2013 , Cataldo Bascunan et al. 2019 ). Intravenous 5-HTP infusion into late-lactation dairy cows increased circulating glucose and free

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0280
Volume/Issue:
Volume 257: Issue 3
Restricted access
Malin Hedengran Faulds
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Chunyan Zhao
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Karin Dahlman-Wright
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Jan-Åke Gustafsson Department of Biosciences and Nutrition, Center for Nuclear Receptors and Cell Signaling, Novum, Karolinska Institutet, S-141 83 Huddinge, Sweden

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lipogenesis/lipolysis Organisms store energy for later use during times of nutrient scarcity. Excess energy is stored as triacylglycerol (TAG) in lipid droplets produced by lipogenesis. When energy is required, TAGs are catabolized into FFAs via lipolytic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0044
Volume/Issue:
Volume 212: Issue 1
Free access
Srilaxmi Kalavalapalli Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Fernando Bril Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Joy Guingab Department of Pathology, University of Florida, Gainesville, Florida, USA

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Ariana Vergara Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA

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Timothy J Garrett Department of Pathology, University of Florida, Gainesville, Florida, USA

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Nishanth E Sunny Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA

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Kenneth Cusi Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida, Gainesville, Florida, USA
Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veterans Administration Medical Center (VAMC), Gainesville, Florida, USA

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and lipogenesis, respectively. There was also an amelioration by exenatide administration in the expression of genes linked to inflammation and fibrosis, as indicated by significantly lower mRNA levels of tumor necrosis factor a ( Tnfa ), tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0007
Volume/Issue:
Volume 241: Issue 3
Free access
Chunyan Zhao Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden

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Karin Dahlman-Wright Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden

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needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0271
Volume/Issue:
Volume 204: Issue 3
Free access
Liisa Ailanen Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Suvi T Ruohonen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Laura H Vähätalo Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Katja Tuomainen Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Kim Eerola Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku, Turku, Finland

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Henriikka Salomäki-Myftari Institute of Biomedicine and Turku Center for Disease Modelling; Drug Research Doctoral Program, University of Turku, Turku, Finland

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Matias Röyttä Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland

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Asta Laiho Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Markku Ahotupa Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

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Helena Gylling Department of Internal Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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Eriika Savontaus Institute of Biomedicine and Turku Center for Disease Modelling, University of Turku; Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland

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whereby NPY alters energy metabolism have been elucidated in animal models. Central NPY is known to suppress the sympathetic tone, energy expenditure and brown adipose tissue (BAT) thermogenic activity, and to increase lipogenesis in white adipose tissue

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0223
Volume/Issue:
Volume 234: Issue 1
Free access
Sheree D Martin Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Australia

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Sean L McGee Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Australia

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& Bruning 2012 ). For example, there is evidence in type 2 diabetes that the ability of insulin to promote hepatic lipogenesis is maintained, despite impairments in insulin-stimulated glycogen synthesis ( Shimomura et al . 2000 ). The nature of this

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0037
Volume/Issue:
Volume 237: Issue 2
Free access
Samuel M Lee Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Muratalla Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Marta Sierra-Cruz Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Cordoba-Chacon Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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promoter-driven Cre mice show that PPARα controls adipocyte metabolism by reducing lipogenesis, inflammation, and cholesterol ester accumulation to prevent adiposity ( Hinds et al. 2021 ). Another example would be the cardiomyocyte-specific PPARγ

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0155
Volume/Issue:
Volume 257: Issue 1
Free access
Sarah L Armour Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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Jade E Stanley Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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James Cantley Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK

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E Danielle Dean Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA

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Jakob G Knudsen Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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committed step in de novo lipogenesis: ACC1 activity is critical for regulated glucagon secretion and alpha cell growth. Malonyl-CoA is utilised by fatty acid synthase (FASN) to generate free fatty acids, which can be converted to fatty acyl-CoA esters via

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0081
Volume/Issue:
Volume 259: Issue 1
Free access