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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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triglyceride (TG) concentrations ( P <0.001; Fig. 4 A, B and C). Enzymes involved in the regulation of fatty acid oxidation and lipogenesis were measured in subcutaneous WAT and BAT by immunoblotting in order to perform an initial investigation of the
Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain
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Institut d’Investigació Sanitària de Palma (IdISPa), Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain
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above in combination with increased lipogenesis, such as the higher Srebp1c mRNA levels shown, caused hepatic triglyceride accumulation. In contrast, E2 replacement ameliorated mitochondrial function and biogenesis of OVX rats, accompanied by
Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA
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Vita Plus Corporation, Madison, Wisconsin, USA
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Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA
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Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA
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Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA
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Endocrinologh and Reproductive Physiology Graduate Training Program, University of Wisconsin, Madison, Wisconsin, USA
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gluconeogenesis, lipolysis, and lipogenesis, among others ( Kim et al. 2010 , Sumara et al. 2012 , Laporta et al. 2013 , Cataldo Bascunan et al. 2019 ). Intravenous 5-HTP infusion into late-lactation dairy cows increased circulating glucose and free
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lipogenesis/lipolysis Organisms store energy for later use during times of nutrient scarcity. Excess energy is stored as triacylglycerol (TAG) in lipid droplets produced by lipogenesis. When energy is required, TAGs are catabolized into FFAs via lipolytic
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Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veterans Administration Medical Center (VAMC), Gainesville, Florida, USA
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and lipogenesis, respectively. There was also an amelioration by exenatide administration in the expression of genes linked to inflammation and fibrosis, as indicated by significantly lower mRNA levels of tumor necrosis factor a ( Tnfa ), tissue
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needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the
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whereby NPY alters energy metabolism have been elucidated in animal models. Central NPY is known to suppress the sympathetic tone, energy expenditure and brown adipose tissue (BAT) thermogenic activity, and to increase lipogenesis in white adipose tissue
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& Bruning 2012 ). For example, there is evidence in type 2 diabetes that the ability of insulin to promote hepatic lipogenesis is maintained, despite impairments in insulin-stimulated glycogen synthesis ( Shimomura et al . 2000 ). The nature of this
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promoter-driven Cre mice show that PPARα controls adipocyte metabolism by reducing lipogenesis, inflammation, and cholesterol ester accumulation to prevent adiposity ( Hinds et al. 2021 ). Another example would be the cardiomyocyte-specific PPARγ
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Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
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committed step in de novo lipogenesis: ACC1 activity is critical for regulated glucagon secretion and alpha cell growth. Malonyl-CoA is utilised by fatty acid synthase (FASN) to generate free fatty acids, which can be converted to fatty acyl-CoA esters via