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hyperinsulinemia, type 2 diabetes mellitus, obesity, dyslipidemia, metabolic syndrome, and cardiovascular complications (reviewed by Carvalho et al. 2018 ). Insulin resistance is observed up to 47% in lean PCOS and up to 76% in obese PCOS ( Diamanti
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Introduction The prevalence of metabolic syndrome and type 2 diabetes (T2D) is increasing in an epidemic-like fashion, and it is particularly pronounced in developing countries currently undergoing rapid economic transition and experiencing
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epigenetics to obesity, hypertension, and/or metabolic syndrome is less clear ( Egger et al . 2004 , Gallou-Kabani & Junien 2005 ). We can speculate that obesity-related hypertension develops as a consequence of ‘errors’ in well-coordinated regulatory
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the stage of infection (i.e., preclinical compared with clinical). Specifically, in the 139H scrapie model, a severe preclinical anabolic syndrome was evident and was more pronounced when hamsters were non-fasted, whereas in the HY TME model a severe
Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
Birmingham and Midland Eye Centre, Dudley Road, Birmingham B18 7QU, UK
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
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Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham,
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), ocular surface renewal ( Onyimba et al. 2006 ), inflammation ( Thieringer et al. 2001 , Zhang et al. 2005 ) and the metabolic syndrome – a cluster of cardiovascular risk factors, including hypertension, obesity, hyperlipidaemia and insulin
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Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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95 1028 – 1037 . ( doi:10.1038/sj.bjc.6603360 ) Bjorndal B Burri L Staalesen V Skorve J Berge RK 2011 Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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activated BAT. These observations provide persuasive evidence for a significant metabolic role of BAT in humans. Glucocorticoids (GCs) play a critical role in the regulation of energy balance. Chronic GC excess, as exemplified in Cushing's syndrome, results
University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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University of Lübeck, Department of Internal Medicine I, 23538 Lübeck, Germany
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symptoms of the metabolic syndrome including insulin resistance and obesity ( Masuzaki et al. 2001 ). Furthermore, studies in humans confirm that local overexpression of 11β-HSD-1 in adipocytes might contribute to insulin resistance found in obesity
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characterized by phenotypic features of non-obese metabolic syndrome, whereas ANGII-500-treated rats exhibited diabetes-like symptoms. Rodents infused with a broad range of ANGII concentrations (10–1440 ng/kg/min) via implantable osmotic minipumps have been
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, WELBIO, Université Paris Diderot, Euroscreen SA, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium
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Introduction Obesity and associated disorders, such as type 2 diabetes, metabolic syndrome, and cardiovascular diseases, constitute a rapidly growing health problem in Western countries. According to the World Health Organization, worldwide obesity