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S Morimoto Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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C A Mendoza-Rodríguez Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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M Hiriart Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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M E Larrieta Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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P Vital Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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M A Cerbón Instituto Nacional de Ciencias Médicas y Nutrición, SZ Vasco de Quiroga 15, Tlalpan 14000, D F México, México
Facultad de Química and
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Coyoacan 04510, D F México, México

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progressive hyperglycemia, accompanied by lymphocytic infiltration of pancreatic islets. In some basic aspects, this model mimics recent-onset IDDM in human patients ( O’Brien et al. 1996 ). There is evidence of sexual dimorphism in the incidence and

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Melody L Allensworth-James Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Angela Odle Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Anessa Haney Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Melanie MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Angus MacNicol Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Gwen Childs Department of Neurobiology and Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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at PND 8–10 corresponds with the reduction in GH at PND 8 in those females. Since Pou1f1 is also reduced at PND 15, we need to investigate whether or not Pou1f1 remains down throughout development in this model. We do see sexual dimorphism of Pou1f1

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Takeshi Iwasa Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Toshiya Matsuzaki Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Masahiro Murakami Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Riyo Kinouchi Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Ganbat Gereltsetseg Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Shinobu Fujisawa Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Akira Kuwahara Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Toshiyuki Yasui Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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Minoru Irahara Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan

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putative physiopathological implications . Peptides 30 139 – 145 doi:10.1016/j.peptides.2008.06.007 . Clarkson J Herbison AE 2006 Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to

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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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striking sexual dimorphism . Journal of Physiology 549 835 – 843 . Oishi Y Okuda M Takahashi H Fujii T Morii S 1993 Cellular proliferation in the anterior pituitary gland of normal adult rats: influences of sex, estrous cycle, and

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Duarte Pignatelli Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200-319 Porto, Portugal
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK

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Fang Xiao Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200-319 Porto, Portugal
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK

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Alexandra M Gouveia Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200-319 Porto, Portugal
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK

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Jorge G Ferreira Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200-319 Porto, Portugal
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK

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Gavin P Vinson Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200-319 Porto, Portugal
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK

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attenuation of this growth after 60 days. The adrenal weight as well as the area of the cortex (Fig. 1 ) and zona fasciculata (Fig. 2 ), but not the area of the zona reticularis (Fig. 3 ), exhibited sexual divergence after puberty, being larger in

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Cristina Aresté
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M Jesús Melià
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Joan Isern
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José Luis Tovar
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Anna Meseguer
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the spontaneously hypertensive rat model, a sexual dimorphism in BP has also been observed ( Chen & Meng 1991 , Turner et al. 1991 , Phillips et al. 1997 , Reckelhoff et al. 1999 ). Despite the scarce information on sex-related BP differences

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Emily Panagiotidou Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Sophia Zerva Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Dimitra J Mitsiou Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Michael N Alexis Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Efthymia Kitraki Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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robust and extended in prepubertal than mature male rats, reaching adult levels after postnatal day 50. Sexual dimorphism of BPA effects on the stress axis Perinatal BPA exposure often exerts a sex-specific effect on their offspring's physiology and

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Shuisheng Li State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Yong Zhang State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Yun Liu State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Xigui Huang State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Weiren Huang State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Danqi Lu State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Pei Zhu State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Yu Shi State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Christopher H K Cheng State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Xiaochun Liu State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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Haoran Lin State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China
State Key Laboratory of Biocontrol, Department of Biochemistry, College of Ocean, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China

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, the mechanism of sexual dimorphism, the regulation of seasonal reproduction, and the integration of energy homeostasis and reproduction ( Kauffman et al . 2007 , Popa et al . 2008 ). In lower vertebrates, however, the role and significance of the

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Nerine T Joseph Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Kevin Morgan Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robin Sellar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Derek McBride Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robert P Millar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Ian C Dunn Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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due to the age of animals used in different studies. The sexual dimorphism in cGnRH-R-III expression, where levels of mRNA are higher in juvenile males compared with juvenile females, is consistent with the LH response to photo-stimulation seen in

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Saira Hameed Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Channa N Jayasena Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Waljit S Dhillo Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons . Endocrinology 147 5817 – 5825 doi:10.1210/en.2006-0787 . Clarkson J d'Anglemont de Tassigny X Moreno

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