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al. 2018 ) was applied to the subsequent cell experiments, cAMP is a ubiquitous second messenger that plays an important role in a wide range of cells and multiple signaling pathways. The cAMP signaling pathway is very important for early brown
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-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation . Experimental and Molecular Medicine 50 e432 . ( https://doi.org/10.1038/emm.2017.245 ) Kim JW Kim SM Park JS Hwang SH Choi JW Jung KA Ryu JG Lee SY Kwok
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, which has been mechanistically linked to the enhanced thermogenic programs in white and brown adipocytes and higher fat oxidation ( Bonet et al. 2012 ). The role of vitamin A supplementation as an insulin sensitizer acting independently of changes in