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-privileged site supporting the nidation of a semiallogenic fetus ( Gellersen & Brosens 2003 , Mesiano et al . 2011 ). The decidualization of the stromal cells also occurs in the absence of pregnancy and the declining P 4 levels trigger several effects, such as
Department of Biology, Shantou University, Shantou, China
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Introduction Embryo implantation is the attachment of the embryo to the uterine luminal epithelium followed by invasion of embryos into the underlying stromal bed. Once embryos are implanted, uterine stromal cells will undergo decidualization
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
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Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
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Introduction In mammals, the reproductive process represents a complex and highly coordinated biological phenomenon, which involves embryo implantation, decidualization and placental development ( Cakmak & Taylor 2011 , Hemberger et al
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
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Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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regulatory effects of high-level insulin on the endometrium. Our previous study found that high levels of insulin could result in impaired endometrial receptivity and further affect endometrial decidualization in early pregnant mice ( Li et al. 2017
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Introduction Two of the most crucial events in early pregnancy in species with invasively implanting embryos, such as humans and mice, are embryo implantation and endometrial decidualization. Embryo implantation is a tightly regulated series
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
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Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
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Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
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Introduction Decidualization of endometrial stromal cells (ESCs) is the hallmark of tissue remodeling which supports embryo implantation and proper placental development ( Gellersen & Brosens 2014 , Yu et al. 2017 , Liu et al. 2017
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
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Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
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Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
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Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
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Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
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transformation process involving a proliferation-differentiation transition that is defined as decidualization ( Gellersen & Brosens 2014 ) and is sustained by elevated P 4 levels in the luteal phase ( Gellersen & Brosens 2003 ). It has been confirmed that
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Introduction Decidualization, a process where uterine stromal cells undergo extensive proliferation and differentiation into decidual cells, is essential for continued embryonic development and successful pregnancy ( Dey et al . 2004 , Zhang
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had not been reported. Endometrial decidualization is an important step in embryonic development and fetal growth. In particular, this process is critical in establishing maternal–fetal communication and provide a good nutritional environment for
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be regulated by Hoxa10 gene, which was essential for decidualization ( Benson et al . 1996 , Germeyer et al . 2009 , Doherty et al . 2011 , Zhang et al . 2013 ). According to our (B Guo and X-C Tian unpublished observations) microarray data