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Christina Antza Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Georgios Kostopoulos Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

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Samiul Mostafa Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Krishnarajah Nirantharakumar Institute of Applied Health Research, University of Birmingham, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Abd Tahrani Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Department of Diabetes and Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Centre of Endocrinology Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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linking sleep duration to obesity and T2DM. There are multiple plausible mechanisms that lead to changes to energy balance, beta cell function and insulin resistance ( Fig. 1 ). Figure 1 The mechanisms between short sleep duration and type 2

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Marion Régnier UCLouvain, Université Catholique de Louvain, WELBIO – Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium

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Matthias Van Hul UCLouvain, Université Catholique de Louvain, WELBIO – Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium

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Claude Knauf Université Paul Sabatier, Toulouse III, INSERM U1220, Institut de Recherche en Santé Digestive (IRSD), CHU Purpan, Place du Docteur Baylac, Toulouse Cedex 3, France
European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium

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Patrice D Cani UCLouvain, Université Catholique de Louvain, WELBIO – Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium
European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium

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metabolic abnormalities, prevention remains the greatest challenge. Among the different factors contributing to the regulation of energy balance, the microorganisms that reside in the human gut (called the gut microbiota) have received increasing attention

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Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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overexpression affected energy balance. Recombinant adenovirus (Ad-Asprosin) were generated and locally injected into the groin subcutaneous white adipose tissue to elevate the level of asprosin in vivo (Supplementary Fig. 1B, C and D). The whole-body oxygen

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Lei Du State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yang Wang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Cong-Rong Li State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Liang-Jian Chen State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Jin-Yang Cai State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Zheng-Rong Xia Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Wen-Tao Zeng Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Zi-Bin Wang Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Xi-Chen Chen Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Fan Hu State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Dong Zhang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Xiao-Wei Xing The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhi-Xia Yang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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. ( https://doi.org/10.1016/j.fertnstert.2008.11.025 ) Roa J Tena-Sempere M 2010 Energy balance and puberty onset: emerging role of central mTOR signaling . Trends in Endocrinology and Metabolism 21 519 – 528 . ( https://doi.org/10.1016/j

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Nicole G Barra Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Fernando F Anhê Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Joseph F Cavallari Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Anita M Singh Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Darryl Y Chan Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Jonathan D Schertzer Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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digestion and intestinal absorption of dietary components and energy content is a key mechanism by which bacteria influence energy balance ( Bäckhed et al. 2004 ). Metabolic disease states, like obesity, can alter the gut microbiota to promote more energy

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