Search Results
Search for other papers by R Paul Robertson in
Google Scholar
PubMed
Introduction The editors asked that I write a brief introductory article for this special collection, which focuses on scientific advances in glucagon research and its clinical impacts. In doing so, I will provide a short history of glucagon
Search for other papers by Jasleen Kaur in
Google Scholar
PubMed
Search for other papers by Elizabeth R Seaquist in
Google Scholar
PubMed
Introduction Glucagon is a 29 amino acid pancreatic peptide hormone secreted by the pancreatic alpha cells. It is derived from the precursor hormone proglucagon, which is also a precursor for glucagon-like gut peptides ( Sandoval & D
Search for other papers by Rui Gao in
Google Scholar
PubMed
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
Search for other papers by Samuel Acreman in
Google Scholar
PubMed
Search for other papers by Jinfang Ma in
Google Scholar
PubMed
Search for other papers by Fernando Abdulkader in
Google Scholar
PubMed
Search for other papers by Anna Wendt in
Google Scholar
PubMed
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Search for other papers by Quan Zhang in
Google Scholar
PubMed
Introduction In the body, blood glucose levels are kept within a narrow range by concerted action of glucagon and insulin, the glucose-regulating hormones secreted by α- and β-cells, respectively ( Göke 2008 ). Whereas the islet α-cells were
Search for other papers by James Cantley in
Google Scholar
PubMed
Department of Medicine, Université de Montréal, Montréal, QC, Canada
Search for other papers by Vincent Poitout in
Google Scholar
PubMed
Department of Medicine, University of Washington, Seattle, Washington, USA
Search for other papers by Rebecca L Hull-Meichle in
Google Scholar
PubMed
Glucagon, the principal hormone produced by pancreatic islet alpha (α) cells, has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Accordingly, glucagon has been utilised as a
Search for other papers by Elliott P Brooks in
Google Scholar
PubMed
Search for other papers by Lori Sussel in
Google Scholar
PubMed
Introduction α cells are one of four major endocrine cell types that reside in adult pancreatic endocrine clusters called the Islets of Langerhans. The islet α cells secrete the hormone glucagon in response to hypoglycemic conditions to
Search for other papers by Sarah L Armour in
Google Scholar
PubMed
Search for other papers by Jade E Stanley in
Google Scholar
PubMed
Search for other papers by James Cantley in
Google Scholar
PubMed
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
Search for other papers by E Danielle Dean in
Google Scholar
PubMed
Search for other papers by Jakob G Knudsen in
Google Scholar
PubMed
Introduction Glucagon is secreted from alpha cells located in pancreatic islets of Langerhans and is an important counter-regulatory hormone to insulin, acting to increase blood glucose. Indeed, it was this physiological hyperglycaemic effect
Search for other papers by Yasminye D Pettway in
Google Scholar
PubMed
Search for other papers by Diane C Saunders in
Google Scholar
PubMed
Search for other papers by Marcela Brissova in
Google Scholar
PubMed
Introduction Twenty-five years after the discovery of glucagon in 1923, the pancreatic α cell was identified as its source ( Sutherland & De Duve 1948 ). Since then, the α cell has gained recognition for its physiologic role in preventing life
