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Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
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Department of Medicine, University of Toronto, Toronto, ON, Canada
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Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada
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secretion, appetite regulation and gut motility) ( Gibbs et al. 1997 , Suzuki et al. 2010 ). However, of all the potential endocrine factors that could contribute to maternal metabolic adaptations to pregnancy, glucagon-like peptide-1 (GLP-1) is
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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hormones ( Cani et al. 2004 ). Indeed, both oligofructose and inulin have the capacity to reduce dietary intake in rodents by a mechanism that involves anorexigenic and orexigenic gut hormones, that is, an increase in glucagon-like peptide 1 (GLP-1) and
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Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada
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reducing adiposity, as shown by studies in Gpr55 −/− mice ( Meadows et al. 2016 , Lipina et al. 2019 , Ramírez-Orozco et al. 2019 ); (5) GPR119 has well established incretin actions by enhancing glucagon-like peptide-1 secretion from intestinal
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-inducing hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) ( da Silva et al. 2020 ). In this context, the modulation of gut microbiota by promoting the growth of some specific bacteria by a prebiotic approach can be an effective strategy to reverse
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gut microbes by increasing SCFA-producing bacteria and mucin-degrading Akkermansia muciniphila while increasing intestinal glucose absorption and glucagon-like peptide-1 production ( McCreight et al. 2016 , Vallianou et al. 2019 ). Although