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Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
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when β-cell dysfunction or loss leads to an inability to release enough insulin to control glucose. Other islet endocrine cell types include glucagon-secreting α-cells, δ-, pancreatic polypeptide (PP), and ε-cells. Insulin reduces blood glucose by
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. Figure 2 Representative histologically stained islets from type 1 diabetes pancreas. (A) An insulin-containing islet (ICI) with no evidence of immune cell infiltration (Insulin – brown; glucagon – pink, nPOD donor 6211). (B) An ICI with evidence of a