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Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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glucose, repressing hepatic glucose production and facilitating glucose uptake in adipose tissue and skeletal muscle while glucagon secretion generally opposes these actions ( Campbell & Newgard 2021 ). Further, adipocytes secrete adipokines, including

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Banrida Wahlang Department of Medicine, School of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Louisville, Louisville, Kentucky, USA
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA

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al. 2021 ), inhibiting insulin production and subsequent glucose uptake ( Lee et al. 2018 ), and altering secretory levels of hormones like leptin and glucagon-like peptide-1 ( Shannon et al. 2019 , Wahlang et al. 2013 b ). Apart from

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