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Sarah L Armour Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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Jade E Stanley Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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James Cantley Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK

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E Danielle Dean Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA

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Jakob G Knudsen Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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committed step in de novo lipogenesis: ACC1 activity is critical for regulated glucagon secretion and alpha cell growth. Malonyl-CoA is utilised by fatty acid synthase (FASN) to generate free fatty acids, which can be converted to fatty acyl-CoA esters via

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0081
Volume/Issue:
Volume 259: Issue 1
Free access
Jasleen Kaur Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Elizabeth R Seaquist Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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activated in response to a fall in plasma glucose to a value less than 70 mg/dL ( Hawkes et al. 2019 ). Activation of the sympathetic nervous system, and cortisol and growth hormone secretion also occur as the glucose falls below 60–65 mg/dL ( Hawkes et

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0278
Volume/Issue:
Volume 257: Issue 1
Free access
Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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large part due to the development and growth of advanced single-cell sequencing technologies and unbiased molecular techniques, along with the increased availability of human islets that harbor a greater proportion of α cells. Recent work has revealed

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0297
Volume/Issue:
Volume 258: Issue 2
Free access
Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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and while our understanding of human α cell biology is ever evolving, there are many opportunities for future studies. For example, the vast majority of α cell genes altered in T2D have no known role in islet cell growth or function, emphasizing the

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0298
Volume/Issue:
Volume 258: Issue 1
Free access