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The glucocorticoid receptor in skeletal health and disease: insights from targeted knockout mice

Eugenie Macfarlane

Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou

Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel

Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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by dynamic histomorphometry, whereas bone formation was unchanged in GR Runx2 treated mice. Importantly, the expression of Col1a1, a marker of osteoblast function, was significantly reduced after treatment with prednisolone in wild-type but not GR