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Hormone replacement therapy is a tenet of endocrinology. The recognition that growth hormone (GH) is biologically important beyond promoting growth in childhood has only been accepted recently despite its isolation over 70 years ago. In addition
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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Introduction The prostate gland is a hormonally regulated organ that commonly becomes bothersome with age. Benign prostatic hyperplasia and prostate cancer have different aetiologies, but both have an inestimable impact on patients and their
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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Structurally related activins and inhibins coordinate the hypothalamic–pituitary–gonadal axis Inhibins were first postulated a century ago as gonadally derived hormones that could influence pituitary function and follicle-stimulating hormone
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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. Overview of glucocorticoid receptor signalling Regulation of glucocorticoid synthesis, systemic release, and local availability Endogenous glucocorticoids (cortisol in humans and corticosterone in rodents) are essential steroid hormones that are
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marsupial is that gonadal differentiation and virilisation of the urogenital tract (which occur in utero in man and mouse) take place after birth ( Fig. 1 ), so the young can be directly manipulated with hormones, growth factors or inhibitors without the
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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five types of hormone-producing neuroendocrine cells: somatotrophs, lactotrophs, gonadotrophs, corticotrophs and thyrotrophs. Several other cell types are scattered through the pituitary: folliculostellate cells, follicular cells, marginal zone cells
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, aberrant glucose metabolism and dyslipidaemia as features of the metabolic syndrome ( Umapathysivam et al. 2022 ). The proportionate fall in serum testosterone and sex hormone binding globulin (SHBG) concentrations under these circumstances is inherently
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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narrative review we outline the current knowledge surrounding ACE2 as the receptor for SARS-CoV-2, its interacting partners, hormonal regulation, and functions, highlighting the importance of ACE2 dysregulation in the pathogenesis of COVID-19. We also
Department of Medicine, Monash University, Clayton, Victoria, Australia
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human mineralocorticoid receptor, with the hinge region between the DBD and LBD. Below the linear schematic is the crystal structure of two DBD monomers with the hormone response element shown below the DNA. Four zinc atoms coordinate the zinc fingers
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia
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Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia
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Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia
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common biological underpinnings ( Figure 1 ). Taking together the understanding of recent advances in PCOS genetics, Dapas et al. proposed an updated model of PCOS pathogenesis, ‘Because the characteristic hormonal disruptions in PCOS self-propagate in
