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The glucocorticoid receptor in skeletal health and disease: insights from targeted knockout mice

Eugenie Macfarlane

Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou

Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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, and

Markus J Seibel

Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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synthesised in and released by the adrenal cortex. The synthesis and secretion of glucocorticoids is controlled by the hypothalamus and pituitary where signals such as light, exercise, hypoglycaemia, infection, injury, or stress trigger the hypothalamic