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. Similarly, plaque formation in the metformin-treated animals was attenuated, with reduced monocyte infiltration ( Vasamsetti et al. 2015 ). Macrophages/monocytes Macrophages and monocytes are cells of the innate immune system that play a crucial
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resources, Zhang et al. showed that several AMPs are depleted in the faeces of T2D subjects in comparison to those in prediabetic and healthy subjects ( Zhong et al. 2019 ). In addition to the innate immune system, the adaptive immune system is another
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cells but not alpha cells to the immune system in pre-diabetes . Journal of Autoimmunity 119 102628 . ( https://doi.org/10.1016/j.jaut.2021.102628 ) Bogdani M 2016 Thinking outside the cell: a key role for hyaluronan in the pathogenesis of human
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immune system . Annual Review of Immunology 34 369 – 394 . ( https://doi.org/10.1146/annurev-immunol-041015-055427 ) Le Roy CI Bowyer RCE Castillo-Fernandez JE Pallister T Menni C Steves CJ Berry SE Spector TD Bell JT 2019