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Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

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Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

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abnormalities and inflammation ( Campbell-Thompson et al. 2015 ), rare donors with evidence of amyloid deposition ( Westermark et al. 2017 , Denroche & Verchere 2018 , Beery et al. 2019 ), and multidisciplinary evidence for viral infections ( Dunne et

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James Cantley School of Medicine, University of Dundee, Dundee, Scotland, UK

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Decio Eizirik ULB Center for Diabetes Research, Medical Faculty, Université Libre De Bruxelles, Brussels, Belgium

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autoimmunity, which has important implications for efforts to protect, regenerate and restore endogenous beta-cell function. A timely review of the histological evidence for inflammation, viral infection and endoplasmic reticulum (ER stress in the aetiology of

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Pieter-Jan Martens Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Conny Gysemans Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Chantal Mathieu Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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more cells of the immune system ( Cardozo et al. 2003 ). Interestingly, in the presence of inflammation, beta cells overexpress HLA class I molecules creating an additional homing beacon for cytotoxic T cells ( Richardson et al. 2016 ). Recently, it

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Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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.02.016 ) Atkinson MA Eisenbarth GS 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment . Lancet 358 221 – 229 ( https://doi.org/10.1016/S0140-6736(0105415-0 ) Barra JM Tse HM 2018 Redox-dependent inflammation in islet

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