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abnormalities and inflammation ( Campbell-Thompson et al. 2015 ), rare donors with evidence of amyloid deposition ( Westermark et al. 2017 , Denroche & Verchere 2018 , Beery et al. 2019 ), and multidisciplinary evidence for viral infections ( Dunne et
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autoimmunity, which has important implications for efforts to protect, regenerate and restore endogenous beta-cell function. A timely review of the histological evidence for inflammation, viral infection and endoplasmic reticulum (ER stress in the aetiology of
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more cells of the immune system ( Cardozo et al. 2003 ). Interestingly, in the presence of inflammation, beta cells overexpress HLA class I molecules creating an additional homing beacon for cytotoxic T cells ( Richardson et al. 2016 ). Recently, it
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Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
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.02.016 ) Atkinson MA Eisenbarth GS 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment . Lancet 358 221 – 229 ( https://doi.org/10.1016/S0140-6736(0105415-0 ) Barra JM Tse HM 2018 Redox-dependent inflammation in islet