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Ken KY Ho Garvan Institute of Medical Research, St. Vincent’s Hospital and the UNSW Sydney, Sydney, New South Wales, Australia

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Anthony J O’Sullivan St. George Hospital and the Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia

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Morton G Burt Southern Adelaide Diabetes and Endocrine, Flinders Medical Centre and College of Medicine and Public Health, and Flinders University, Adelaide, South Australia, Australia

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Kidney GFR, ECW, and vascular volume Bone Growth and turnover Liver Growth factors and substrate metabolism Fat Lipid utilisation Skin Exocrine function and hair growth Brain Neurogenesis ECW

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Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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are produced by a number of tissues in addition to the gonads, including the kidney ( Meunier et al. 1988 ), bone ( Broxmeyer et al. 1988 ), lungs, liver, heart ( Chen & Johnson 1996 ), adipose tissue ( Sjöholm et al. 2006 ), breast ( Di Loreto

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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a ). ACE2 can be found in most tissues and organs of the body, including the lung, cardiovascular system, gastrointestinal tract, renal system, brain and nervous system, liver, pancreas, gallbladder, as well as the male and female reproductive

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Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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fetal testis and non-gonadal tissues has been reinforced. Measuring plasma and tissue levels of steroids implicated in both pathways shows that placental progesterone and several other tissues including the liver and adrenal act as a substrate to produce

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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obesity, is associated with T2D risk even if BMI is normal ( Janiszewski et al. 2007 ). Abdominal obesity, where fat accumulates around the viscera and in the liver and infiltrates skeletal muscles mechanistically underpins the metabolic syndrome, which

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Emma J Hamilton Medical School, University of Western Australia, Fiona Stanley Hospital, Murdoch and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

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Stephen M Twigg Central Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

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SM 2015 An association of large-fibre peripheral nerve dysfunction with non-invasive measures of liver fibrosis secondary to non-alcoholic fatty liver disease in diabetes . Journal of Diabetes and its Complications 29 1240 – 1247 . ( https

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Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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1 and 2 (11β-HSD1 and 11β-HSD2, respectively). 11β-HSD1 acts as a reductase catalysing the conversion of inactive cortisone to active cortisol and is highly expressed in metabolic tissues such as the liver, adipose tissue, and bone. Conversely, 11β

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