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Kidney GFR, ECW, and vascular volume Bone Growth and turnover Liver Growth factors and substrate metabolism Fat Lipid utilisation Skin Exocrine function and hair growth Brain Neurogenesis ECW
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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are produced by a number of tissues in addition to the gonads, including the kidney ( Meunier et al. 1988 ), bone ( Broxmeyer et al. 1988 ), lungs, liver, heart ( Chen & Johnson 1996 ), adipose tissue ( Sjöholm et al. 2006 ), breast ( Di Loreto
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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a ). ACE2 can be found in most tissues and organs of the body, including the lung, cardiovascular system, gastrointestinal tract, renal system, brain and nervous system, liver, pancreas, gallbladder, as well as the male and female reproductive
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fetal testis and non-gonadal tissues has been reinforced. Measuring plasma and tissue levels of steroids implicated in both pathways shows that placental progesterone and several other tissues including the liver and adrenal act as a substrate to produce
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obesity, is associated with T2D risk even if BMI is normal ( Janiszewski et al. 2007 ). Abdominal obesity, where fat accumulates around the viscera and in the liver and infiltrates skeletal muscles mechanistically underpins the metabolic syndrome, which
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SM 2015 An association of large-fibre peripheral nerve dysfunction with non-invasive measures of liver fibrosis secondary to non-alcoholic fatty liver disease in diabetes . Journal of Diabetes and its Complications 29 1240 – 1247 . ( https
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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1 and 2 (11β-HSD1 and 11β-HSD2, respectively). 11β-HSD1 acts as a reductase catalysing the conversion of inactive cortisone to active cortisol and is highly expressed in metabolic tissues such as the liver, adipose tissue, and bone. Conversely, 11β