Search Results
Search for other papers by Sarah L Armour in
Google Scholar
PubMed
Search for other papers by Jade E Stanley in
Google Scholar
PubMed
Search for other papers by James Cantley in
Google Scholar
PubMed
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
Search for other papers by E Danielle Dean in
Google Scholar
PubMed
Search for other papers by Jakob G Knudsen in
Google Scholar
PubMed
, liver and skeletal muscle when glucose is sparse and glucagon secretion is elevated ( Felig et al. 1969 a , b , Ahlborg et al. 1974 , Mourtzakis et al. 2006 ). In the postprandial phase, sensing of these nutrients also appears important. In
Search for other papers by Jasleen Kaur in
Google Scholar
PubMed
Search for other papers by Elizabeth R Seaquist in
Google Scholar
PubMed
-cells in the islets of the pancreas. In the liver, glucagon antagonizes the effects of insulin by stimulating glycogenolysis and gluconeogenesis, thereby increasing hepatic glucose output. Figure 3 Posttranslational products of proglucagon
Search for other papers by R Paul Robertson in
Google Scholar
PubMed
infused into the portal vein which delivers them to the liver sinusoids. Here, they have normal glucagon responses to amino acids but only partial responses to hypoglycemia ( Paty et al. 2002 , Rickels et al. 2015 ). In the case of autoislet
Search for other papers by Elliott P Brooks in
Google Scholar
PubMed
Search for other papers by Lori Sussel in
Google Scholar
PubMed
). Section 3: α cells have inherent proliferative potential Expanded α cell mass has been well documented in rodent models that have a breakdown of glucagon-liver signaling and in individuals with diabetes. Morphometric analyses of islets from humans with
Search for other papers by James Cantley in
Google Scholar
PubMed
Department of Medicine, Université de Montréal, Montréal, QC, Canada
Search for other papers by Vincent Poitout in
Google Scholar
PubMed
Department of Medicine, University of Washington, Seattle, Washington, USA
Search for other papers by Rebecca L Hull-Meichle in
Google Scholar
PubMed
liver and fat and in thermogenesis. This review also focuses on translational aspects of glucagon, along with current and potential future therapeutic applications. These include closed-loop bihormonal pumps for diabetes treatment and review of work
Search for other papers by Yasminye D Pettway in
Google Scholar
PubMed
Search for other papers by Diane C Saunders in
Google Scholar
PubMed
Search for other papers by Marcela Brissova in
Google Scholar
PubMed
normoglycemia during fasting is achieved through its actions on the liver (reviewed extensively by Jiang & Zhang (2003 )). Briefly, activation of hepatic glucagon receptors (GcgRs) initiates a cAMP-dependent cascade that leads to simultaneous activation of
