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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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glucagon receptor, thereby reducing glucose excursion at the liver. Finally, it must be considered that biased signaling profiles at different receptors will not have provide simple additive effects in vivo . Small molecule orthosteric and allosteric