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Introduction In the healthy liver, hepatocyte growth hormone receptor (GHR)-signaling activates multiple intracellular signal transduction pathways to modulate hepatic function ( Dehkhoda et al. 2018 ). It is well accepted that GH signals
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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in liver was reduced by HFD ( Eckel-Mahan et al . 2013 ). However, another novel source of NAD is Nocturnin, a member of the exonuclease–endonuclease family of proteins, initially considered a deadenylase ( Stubblefield et al . 2018 ), but
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conditions such as cancer, non-alcoholic fatty liver disease and polycystic ovary disease, although clinical evidence supporting the use of metformin in these diseases is scant ( Marshall 2017 ). It has also been proposed as a general 'anti-ageing' drug based
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Introduction Obesity is linked with many cardiometabolic risk factors, such as insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Although lowering body weight is effective for alleviating several of these
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condition that can lead to a variety of diseases, such as type 2 diabetes ( Bhupathiraju & Hu 2016 ), cardiovascular diseases ( Vecchie et al. 2018 ), non-alcoholic fatty liver disease ( Polyzos et al. 2019 ) and even increased risk of cancers ( Salaun
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excess status linked to T2DM Supplementation: ↓BW, adiposity, liver weight ↑blood thyroid hormone (TSH, TT3, FT3, FT4) High I dose: Pancreatic destruction, hyperglycemia Impair beta cell insulin secretion, apoptosis Selenium (Se) Male: 55 µg
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blotting analysis using the HLA-A antibodies. (E and F) Densitometry analysis of (D). HLA-A levels in all main tissues (heart, liver, spleen, lung, kidney, brain, BAT, ovary) were similar among all four groups. Different lowercase alphabets above the