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Emma J Hamilton Medical School, University of Western Australia, Fiona Stanley Hospital, Murdoch and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

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Stephen M Twigg Central Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

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that amongst those with T2DM who had metabolic syndrome compared with those with T2DM but no metabolic syndrome, larger median nerves, increased nerve excitability measures, greater neuropathy clinical scores and lesser related regional corneal nerve

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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, aberrant glucose metabolism and dyslipidaemia as features of the metabolic syndrome ( Umapathysivam et al. 2022 ). The proportionate fall in serum testosterone and sex hormone binding globulin (SHBG) concentrations under these circumstances is inherently

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Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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.33, 95% CI 1.01–1.74) and metabolic syndrome (OR 1.53, 1.22–1.91) in subjects with PA compared to those with essential hypertension ( Monticone et al. 2018 ). Consistent with this, treatment of PA has been shown to increase insulin secretion and

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Ken KY Ho Garvan Institute of Medical Research, St. Vincent’s Hospital and the UNSW Sydney, Sydney, New South Wales, Australia

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Anthony J O’Sullivan St. George Hospital and the Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia

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Morton G Burt Southern Adelaide Diabetes and Endocrine, Flinders Medical Centre and College of Medicine and Public Health, and Flinders University, Adelaide, South Australia, Australia

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extracellular water and body cell mass ( Hoffman et al. 1995 ). The complexion is pale with thin skin, scarcity of body hairs, and obscure venous vasculature. Investigations may reveal mild normochromic normocytic anaemia, metabolic syndrome, and a fatty liver

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Chau Thien Tay Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Rhonda Garrad Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Aya Mousa Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Mahnaz Bahri Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia

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Anju Joham Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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Helena Teede Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia

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manifestations arise in childhood and health impacts evolve across adolescent years and adult life ( Teede et al. 2010 ). PCOS has significant metabolic (obesity, metabolic syndrome, impaired glucose tolerance, type 2 diabetes, cardiovascular risk factors

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