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adiol via an alternate pathway of testosterone metabolism ( Wilson et al. 2003 ) ( Figs 3 and 4 ). In this alternate, or backdoor, pathway ( Auchus 2004 ), the testes make a 3α-reduced derivative of DHT 5α-androstane-3α,17β-diol (adiol) ( Shaw et al
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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Introduction Glucocorticoids are essential endocrine regulators of numerous physiological processes including somatic development, systemic fuel and tissue metabolism, electrolyte homeostasis and immunity. In addition, glucocorticoids also
Department of Medicine, Monash University, Clayton, Victoria, Australia
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. 2011 ) associated with untreated PA. The impact of PA treatment on metabolism is less consistent. Surgical treatment of PA has been shown to improve insulin secretion, first-phase insulin reaction and insulin sensitivity, as well as reduced fasting
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to growth, accumulating evidence had emerged in the last decades supporting the regulatory roles of GH in lipid, protein and glucose metabolism, sodium homeostasis, and body composition. A putative role in adult health can only be established from
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, aberrant glucose metabolism and dyslipidaemia as features of the metabolic syndrome ( Umapathysivam et al. 2022 ). The proportionate fall in serum testosterone and sex hormone binding globulin (SHBG) concentrations under these circumstances is inherently
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states . Journal of Clinical Endocrinology and Metabolism 94 1826 – 1834 . Asa SL Mete O Perry A & Osamura RY 2022 Overview of the 2022 WHO classification of pituitary
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cell bodies in the dorsal root ganglia and high metabolism with metabolic glucose dependence. In recent years, the pathogenesis of DPN has been explored by epidemiological as well as correlative structure–function studies. Issar and colleagues found
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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including inhibin A/B, in addition to the sex steroids oestradiol and progesterone. Significantly, ovarian inactivation is associated with the onset of numerous, often debilitating, physiological insults in women including disrupted metabolism, accelerated
Department of Endocrinology and Diabetes, Monash Health, Victoria, Australia
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practice guidelines on the diagnosis and management of polycystic ovary syndrome: a systematic review and quality assessment study . Journal of Clinical Endocrinology and Metabolism 106 2436 – 2446 . ( https://doi.org/10.1210/clinem/dgab232 ) 33839790
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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L Nammo T , 2005 The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation . Cell Metabolism 2 373 – 384 . ( https://doi.org/10.1016/j.cmet.2005.11.003 ) Galasso V Pons V Profeta P Becher M Brouard S
