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Department of Medicine, Université de Montréal, Montréal, QC, Canada
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Department of Medicine, University of Washington, Seattle, Washington, USA
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Glucagon, the principal hormone produced by pancreatic islet alpha (α) cells, has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Accordingly, glucagon has been utilised as a
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Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA
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glucose metabolism. A current hypothesis is that glucose is taken up by alpha cells and oxidised to ATP. The elevated ATP levels act on pumps and channels present in the plasma membrane, causing changes in membrane potential which ultimately lead to
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). Finally, the GcgR is expressed by α cells, serving as a positive autocrine regulator ( Ma et al. 2004 ). Outside that of glucose homeostasis, other impacts of glucagon on nutrient metabolism are numerous and involve the promotion of β
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metabolism have led to the consideration of glucagon to play a role in the treatment of type 2 diabetes mellitus. For a single, recently published review describing this potential, the reader is referred to the 2012 publication by Unger and Cherrington
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Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
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CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
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glucose metabolism regulates α-cell activity ( Gylfe 2016 ), it is clear that the electrophysiological control of α-cells plays an important role in their nutrient sensing and glucagon secretion. The development of improved patch-clamping techniques
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understanding of the physiology of glucagon, its potential role in the causation of diabetes, and its synergistic effects with other gut hormones in regulating metabolism. In this review article, we aim to summarize the known effects of glucagon and its
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Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes . Molecular Metabolism 5 233 – 244 . ( https://doi.org/10.1016/j.molmet.2016.01.002 ) Ackermann Misfeldt A Costa RH & Gannon M 2008 β-cell proliferation
