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.30 ) Denroche HC Verchere CB 2018 IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants . Journal of Molecular Endocrinology 60 R57– R75 . ( https://doi.org/10.1530/JME-17-0138 ) Dotta F Censini S Van Halteren AG
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Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
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Metabolism 5 233 – 244 . ( https://doi.org/10.1016/j.molmet.2016.01.002 ) Aguayo-Mazzucato C Bonner-Weir S 2018 Pancreatic β cell regeneration as a possible therapy for diabetes . Cell Metabolism 27 57 – 67 . ( https://doi.org/10.1016/j
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Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland
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Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland
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metabolism regulating glucose is disrupted, but this can be the consequence of multiple different metabolic processes which can vary between individuals ( American Diabetes Association 2021 ). While some of these processes influence disease progression, drug
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Stanford Diabetes Research Center, Stanford University, Stanford, California, USA
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regulate the gene expression important for both pancreatic islet-cell development as well as glucose metabolism, including the insulin gene itself ( Yamagata et al. 1996 a ). Patients with heterozygous loss-of-function mutations in HNF4A have a
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Beta cells persist in T1D pancreata without evidence of ongoing beta-cell turnover or neogenesis . Journal of Clinical Endocrinology and Metabolism 102 2647 – 2659 . ( https://doi.org/10.1210/jc.2016-3806 ) Lampeter EF Homberg M Quabeck K
