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Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Adam Hagg

Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea

Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison

Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton

Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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upregulation of activin A and B propeptides was shown to induce skeletal muscle hypertrophy in mice ( Chen et al. 2017 , Walton et al. 2019 ) and block activin-mediated muscle atrophy in various pre-clinical models including the C26 mouse model of cancer