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Not the second fiddle: α cell development, identity, and function in health and diabetes

Elliott P Brooks

Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel

Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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gene, while in β cells PAX6 promotes the expression of insulin, highlighting the potential of PAX6 to have distinct roles when expressed in different cell types ( Gosmain et al. 2007 , Swisa et al. 2017 ). Nkx2.2 -null mice possess a total loss of

Article Type:: Review Article

Collections:: 100 years of glucagon: Anniversary collection

DOI:: https://doi.org/10.1530/JOE-22-0297

Volume/Issue:: Volume 258: Issue 2

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The human α cell in health and disease

Yasminye D Pettway

Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders

Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova

Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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-2018 ) Moffett RC Vasu S Thorens B Drucker DJ & Flatt PR 2014 Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy . PLoS One 9 e96863. ( https://doi.org/10.1371/journal.pone.0096863