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Thomas Willmott Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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Elizabeth C Cottrell Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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malnutrition and stress in pregnancy on both maternal and offspring health. More recently, Lizzy’s research has focussed on trying to develop safe and effective interventions to improve pregnancy outcomes, particularly in high-risk women such as those entering

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0360
Volume/Issue:
Volume 261: Issue 2
Restricted access
Rebecca M Reynolds University/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Adrienne Gordon Charles Perkins Centre, University of Sydney, Sydney, Australia

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. 2017 ). Obesity impacts on health of women across their reproductive lifespan with adverse effects on not only fertility and short-term complications of pregnancy, but also on longer-term health outcomes for both women and their children. Here, we

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0199
Volume/Issue:
Volume 239: Issue 3
Free access
Michaela D Wharfe School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Peter J Mark School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Caitlin S Wyrwoll School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Jeremy T Smith School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Cassandra Yap School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Michael W Clarke School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Brendan J Waddell School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Introduction Maternal physiological adaptations are central to pregnancy success, balancing fetal and placental demands with the maintenance of maternal homeostasis. Among these maternal adaptations, enhanced activity of the hypothalamic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0405
Volume/Issue:
Volume 228: Issue 3
Free access
Caitlin S Wyrwoll School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network

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ramifications for offspring health in later life. Her recent research focuses on the environmental change (particularly heat exposure and drinking water quality) on maternal adaptations to pregnancy and child health outcomes. This work is becoming increasingly

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0030
Volume/Issue:
Volume 259: Issue 1
Free access
Derek S Boeldt Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Mary A Grummer Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ronald R Magness Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ian M Bird Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Introduction Pregnancy is a time of dramatic vascular adaptation. Through initial angiogenesis and then sustained vasodilation, the pregnant uterus achieves the biggest drop in vascular resistance of any organ system. This in turn promotes a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0252
Volume/Issue:
Volume 223: Issue 1
Free access
Harleen Kaur Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Beverly S Muhlhausler CSIRO Nutrition and Health, Adelaide, Australia

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Claire T Roberts Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia

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Kathryn L Gatford Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Introduction The GH–IGF axis is essential for growth and development before and after birth and has important anabolic and metabolic functions in adults. Its role during pregnancy has been less understood and is the primary focus of this

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0087
Volume/Issue:
Volume 251: Issue 3
Free access
Thomas G Hill Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK

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Lorna I F Smith Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

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Inmaculada Ruz-Maldonado Department of Internal Medicine (Endocrinology), Yale University, New Haven, Connecticut, USA

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Peter M Jones Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

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James E Bowe Diabetes Research Group, School of Cardiovascular and Metabolic Medicine and Sciences, King’s College London, London, UK

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Introduction Pregnancy is characterised by a shift in maternal metabolism with a progressive increase in maternal insulin resistance to prioritise nutrient flow to the growing fetus ( Battaglia & Meschia 1978 , Hay 1991 , Baumann et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0218
Volume/Issue:
Volume 260: Issue 2
Open access
Cassandra C Yap School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Michaela D Wharfe School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Peter J Mark School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Brendan J Waddell School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Jeremy T Smith School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0086
Volume/Issue:
Volume 229: Issue 3
Free access
Amanda K Mauro Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Nauman Khurshid Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Danielle M Berdahl Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Amanda C Ampey Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Daniel Adu Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Department of Pediatrics, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Dinesh M Shah Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Derek S Boeldt Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Introduction Preeclampsia (PE) is a hypertensive disorder of pregnancy that occurs in 5–8% of all pregnancies. Significant morbidities can occur to the mother and fetus, and in extreme cases, death can result. Mothers who develop PE and babies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0397
Volume/Issue:
Volume 248: Issue 2
Restricted access
Ankana Ganguly Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK

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Jennifer A Tamblyn Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK

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Sarah Finn-Sell Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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Shiao-Y Chan Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Melissa Westwood Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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Janesh Gupta Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK

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Mark D Kilby Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK

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Stephane R Gross School of Life and Health Sciences, Aston University, Birmingham, UK

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Martin Hewison Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK

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addition to facilitating a good maternal blood supply for nutrition–waste exchange and orchestrating endocrine mediators of pregnancy to maintain maternal physiological changes for an optimal environment for fetal development, the placenta also acts to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0491
Volume/Issue:
Volume 236: Issue 2
Free access