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Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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cell, including cell morphology, molecular profile, and function. We summarize studies characterizing how the α cell adapts to changes in metabolic demand during pregnancy, aging, and obesity. Finally, we compare and contrast how α cell physiology is

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0298
Volume/Issue:
Volume 258: Issue 1
Free access
James Cantley Division of Systems Medicine, School of Medicine, University of Dundee, UK

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Vincent Poitout Montreal Diabetes Research Center, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Department of Medicine, Université de Montréal, Montréal, QC, Canada

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Rebecca L Hull-Meichle Research and Development Service, VA Puget Sound Health Care System, Seattle, Washington, USA
Department of Medicine, University of Washington, Seattle, Washington, USA

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responds to physiological (ageing and pregnancy) and pathological (obesity and diabetes) challenges. Kaur and Seaquist ( Kaur & Sequist 2023 ) review the multiple physiological actions of glucagon, including its role in amino acid and lipid metabolism in

Article Type:
Editorial
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0138
Volume/Issue:
Volume 258: Issue 3
Free access